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DBS Probe with an Array of Flexible, Independent Stimulators

Detailed Technology Description

Efficient Deep Brain Stimulation with Spatiotemporal TuningFlex-fabrication design enables new methods of deep brain stimulation (DBS) by combining phase and amplitude modulated pulses with a Flex-DBS probe. The device consists of an array of flexible, independently actuatable, multi-channel stimulators housed inside an implant. The stimulators slide inside individual conduits and the implant’s distal end flares the electrodes radially outward as the motor array drives them distally. Each stimulation fiber contains up to 16 electrodes and can be custom fabricated based on macroscopic bundling and thermal extrusion techniques.Current DBS Leads have Limited AccessibilityCurrent DBS leads are configured cylindrically, which limits accessibility of the stimulation electric fields to a target of interest with a complicated 3D structure, rendering them unable to provide efficient 3D voltage steering. The Flex-DBS system can be used to create rotating (rather than unidirectional) electrical fields, providing spatiotemporal control of the electrical field direction in 3D space, creating electric fields parallel to axons with specific orientation. The strategies identify a new course for selective neuromodulation based on axonal fiber orientation, which naturally extends from in-plane stimulation to three-dimensional (3D) space, a concept called Rotating Field Phase Steering (RFPS). The reconfigurable Flex-DBS probe solves current target selection precision problems by exploiting the 3D capability of the lead of stimulating entire volume of interest, a design that increases precision of target selection during DBS.BENEFITS AND FEATURES:Spatiotemporally tunedEfficient deep brain stimulationFlex-DBS probe combines phase and amplitude modulated pulsesFlexible, independently actuatable, multi-channel stimulatorsElectrodes flared radially outward as the motor array drives them distally.Creates rotating (rather than unidirectional) electrical fieldsSpatiotemporal control of the electrical field direction in 3D spaceAPPLICATIONS:DBS electrodesNeurosurgery medical devicesSophisticated multichannel and multifunctional neural probes for basic scientific researchParkinson's disease(PD)Essential tremorNeurological and psychiatric disorders (e.g., obsessive compulsive disorder and depression)Phase of Development - Concept; conceptual design and initial simulations completed

Country/Region

USA

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