Multi-Staged Gutta Percha Biomaterial Embedded With Nanodiamond Matrix
Versatile surface chemistry allows a broad-spectrum of antibiotics Antimicrobial Enhanced mechanical properties compare to regular GP Thermal stabilization of the antimicrobial agent adsorbed to the nanodiamond Applicable with traditional obturation techniques
Root canal filling or obturation Orthopedic regenerative medicine Broader tissue engineering
The inventors have developed an improved root canal filling material or obturation material: gutta perchamodified with nanodiamonds and/or nanodiamonds adsorbed with antibiotic/antimicrobial agent(s). The composite can come in different shapes, cone (points) or cylinder (pellet), and can be embedded either in a homogenous or multi-staged manner. By taking advantage of the ND surface chemistry, a broad-spectrum antibiotic, like amoxicillin, can be adsorbed to the ND surface. Furthermore, the modified matrix is compatible with traditional obturation techniques, such as lateral condensation and vertical condensation.
Background There is a widespread need for root canal treatment (RCT) procedures since pulp tissue infection can result from a spectrum of issues including trauma, caries, and periodontitis. The current standard material for RCT obturation is gutta-percha (GP), however, it has been associated with microleakage and poor mechanical properties that leads to fracture and buckling. Detonation nanodiamonds (NDs) are promising drug delivery agents due to their uniquely faceted surfaces with diverse chemical groups, electrostatic properties, and biocompatibility. Related Materials D.-K. Lee, S. V. Kim, A. N. Limansubroto, A. Yen, A. Soundia, C.-Y. Wang, W. Shi, C. Hong, S. Tetradis, Y. Kim, N.-H. Park, M. K. Kang, and D. Ho, Nanodiamond–gutta percha composite biomaterials for root canal therapy, ACS Nano, 2015. Tech ID/UC Case 29423/2018-194-0 Related Cases 2018-194-0
D.-K. Lee, T. Kee, Z. Liang, D. Hsiou, D. Miya, B. Wu, E. Osawa, E. K.-H. Chow, E. C. Sung, M. K. Kang, and D. Ho, Clinical validation of a nanodiamond-embedded thermoplastic biomaterial, Proceedings of the National Academy of Sciences, 2017.
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