Clk1 and/or 4 Inhibitors for the Development of Brite or Beige Fat Cells from Human and Mouse Adipose Derived Stem Cells
- Technology Benefits
- Burn more energy, Store less fat
- Detailed Technology Description
- Our study investigates how inhibiton of Clk kinase activity in developing fat cells can alter the phenotype of cells toward beige or ΓÇ£briteΓÇØ adipocytes. These adipocytes burn more energy and store less triglyceride. This may provide a promising therapeutic strategy for regulating white adipose tissue mass.
- *Abstract
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Researchers at the University of South Florida have shown that certain inhibitorsof Clk 1 and/or 4 induce the expression of UCP1 in differentiating pre-adipocytes. We predict that this marker of ΓÇ£beigeΓÇØ or ΓÇ£briteΓÇØ adipocytes would enhance weight loss since beige adipocytes burn energy rather than store it as triglycerides.
- Country/Region
- USA
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