Live Cell Conjugation Chemistry for Imaging, Sensing, Biomanufacturing, and Cell Therapy
- Summary
- Researchers at Purdue University have developed a new technology that improves the ability to have live cell imaging. This also allows for biomanufacturing enhancement of cells for therapeutic applications, enhanced killing of cancer cells for cell-drug conjugation, and drug delivery in a pH dependent manner to sites of inflammation. This technology is used to functionalize small molecules, proteins, florophores, and PET tracers. It does not use nanoparticles or other vehicles. This allows for the conjugating cell membranes without killing cells. This new technology has the potential to change how surface modification of live cells.
- Technology Benefits
- Functionalized for small molecules, proteins, florophores, and PET tracersNo use of nanoparticles or other vehiclesConjugating cell membranes without killing cells
- Technology Application
- Cell membrane imagingTherapeutic applications
- Detailed Technology Description
- Gaurav ChopraChopra Lab
- Countries
- United States
- Application No.
- None
- *Abstract
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None
- *Background
- Surface modification of live cells has many biomedical applications and therapeutic applications, such as, live cell imaging and cell therapy. Several methods have been explored on this problem, but all of the current solutions show limited time stability. Another issue with current solutions is the reactions used are not compatible with mammalian cells due to toxicity from metal catalyzed chemical modification of membrane proteins. There is a need for a new technology that could improve how surface modification of live cells works.
- *IP Issue Date
- None
- *IP Type
- Provisional
- *Stage of Development
- Concept validated through theory, simulation, or models
- *Web Links
- Purdue Office of Technology CommercializationPurdue Innovation and EntrepreneurshipGaurav ChopraChopra Lab
- Country/Region
- USA
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