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Ultra-sensitive androgen assay

Technology Benefits

Monitoring androgen levels is crucial for several patients. In 2006, 648,000 American men were treated for testosterone deficiency and >200,000 men were diagnosed with prostate cancer. 4-12% of American women of reproductive age suffer from polycysic ovary disease (PSOS), for which increased testosterone is a diagnostic criterion. Although decreasing in frequency, anabolic steroid abuse is still a problem. Furthermore, there is an increased need for monitoring androgen levels in the environment. Current liquid chromatography/mass spectrometry (LC/MS) techniques to measure androgen levels are costly.

Technology Application

- Monitor androgen levels in o men with testosterone deficiency o prostate cancer patients being treated with anti-androgens- Diagnose PSOS- Detect steroid use in athletes

Detailed Technology Description

This assay relies on the concept that the androgen receptor (AR) translocates from the cytoplasm to the nucleus when androgens are present. Patient samples are applied to cells that express androgen receptor tagged with a yellow fluorophore and a nuclear localization sequence fused to a red fluorophore. If androgens are present, yellow fluorescence overlaps with red fluorescence. The results obtained with this assay correlated with results from the same samples analyzed by standard LC/MS techniques.

Application No.

WO2015148549

Others

Stage of Development

Fully developed diagnostic

Looking for Partners

To commercialize this diagnostic tool

Data Availability

Under NDA/CDA

Inventor's Profile

http://profiles.ucsf.edu/fred.schaufele

Tech ID/UC Case