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Anti-O-linked N-acetylglucosamine (O-GlcNAc) Monoclonal Antibodies (23 lines)

Detailed Technology Description
These mouse monoclonalantibodies were generated against a synthetic three-component O-linkedN-acetylglucosamine (O-GlcNAc) immunogen and recognizes GluNAcpepetide/O-GlcNAc. Suitable for ELISA and Western Blot applications. The study of O-GlcNAc,a ubiquitous translation and transcription regulator which is found in a widevariety of proteins, is of great relevance to multiple chronic human andveterinary diseases. These include diabetes (and its effects in the heart,kidneys and eyes), cardiovascular disease, neurodegenerative disordersinvolving both plaque and tangle formation, inflammatory processes, liverdisease, fibrosis, metabolic disorders and cancer. There is fast growingcollection of evidence that O-GlcNAcylation plays a pivotal role in epigenetics.This  a 23 Mab panel was developedspecifically to study the diverse roles of O-GlcNAc and that can be employedfor detection, isolation, and site localization. For details on antigenstrategy, please consult: Chin Fen Teo, et al., Nat Chem Biol. 2010 May; 6(5):338-343. doi:10.1038/nchembio.338 (see link below).
*Abstract

Reagent Description           

Antigen:  GlcNAc

Clones Names:  11C6.E5 (IgG3); 11D6.C11(IgG3); 13F10.G6(IgG2b); 14D9.D4 (IgG2a); 16B9.F1 (IgG1); 16E2.A3 (IgG3); 1D3.D6 (IgG1); 1D5.C1(IgG2a); 1E5.H3 (IgG2a); 1E9.E3 (IgG3); 2A8.F3 (IgG3); 2D5.E6 (IgG3); 3C1.E8(IgG1); 3G5.A2 (IgG2b); 5F6.G4 (IgG3); 5H11.H6 (IgG1); 6B5.A8 (IgG3); 6G3.A5(IgG2a); 7A3.G8.F7 (IgG2a); 7B3.A3 (IgG3); 7B8.F5 (IgG1); 8C3.H2 (IgG3); 8G1.D6(IgG2a)

Reactivity:  GlcNAc

Immunogen:  Synthetic peptide O-GlcNAc

Host:  Mouse

Buffer:  Cell culture supernatant

TestedApplications:  ELISA, WB

Storage:  -80oC

References

Chin Fen Teo,Sampat Ingale, Margreet A. Wolfert, Galal A. Elsayed, Laszlo G. Nöt, John C.Chatham, Lance Wells, and Geert-Jan Boons: Glycopeptide specific monoclonalantibodies suggest new roles for O-GlcNAc. Nat Chem Biol.2010 May ; 6(5): 338-343 doi:10.1038/nchembio.338

Pablo Rios, TomS. Carter, Tiddo J. Mooibroek, Matthew P. Crump, Micke Lisbjerg, MichaelPittelkow, Nitin T. Supekar, Geert-Jan Boons, and Anthony P. Davis: SyntheticReceptors for the High-Affinity Recognition of O-GlcNAc Derivatives. Angew. Chem.Int. Ed. 2016, 55, 3387-3392 http://dx.doi.org/10.1002/anie.201510611
Country/Region
USA

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