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Methods for Producing Neocartilage with Functional Potential

Technology Benefits

Efficacious production of neocartilage Formation of functional human neocartilage similar to native cartilagePotential supplement to TCL treatment to enhance functional propertiesNovel tissue engineering techniques

Technology Application

· Neotissue production (e.g., neocartilage) · Tissue-engineered cartilage-like tissue (TCL) treatment · Tissue engineering applications

Detailed Technology Description

UCI scientists have discovered methods and compositions for producing highly expanded cells with an ability to form neocartilage. The method of cell expansion entails culturing the cells from cadaveric tissue in a cocktail of growth factors and differentiating agents, and culturing in 3-D the expanded cells for redifferentiation in a redifferentiation cocktail. The resulting engineered cells have functional properties comparable to native cartilage and the potential to produce neocartilage. Notably, the invention enables a large quantity of engineered cartilage implants to be produced from a few cells.

Others

State Of Development

In vitro evaluation of native and engineered tissues using cadaveric cartilage Assessed biomechanical and biochemical properties

Tech ID/UC Case

29129/2017-960-0

Related Cases

2017-960-0

Country/Region

USA

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