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Fluorescent Prodrugs
Detailed Technology Description
Technology SummaryResearchers at the University have found phosphonate derivatives that incorporate the properties of prodrugs and fluorescence. These prodrugs allow for entry into a cell, and once cleaved by metabolic or chemical processes, release the active phosphonate. Alongside the active agent being released after a compound is cleaved, the fluorescent property of the compound is also expressed. This allows direct monitoring of the release of the active agent, information that otherwise was unreachable. Advantages Strong pH sensitivity, providing easier cellular entryEnzymatically-cleavable protecting groups, allowing efficient cellular drug delivery
Country/Region
USA
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