Compounds for modulating ferroptosis and treating excitotoxic disorders
- Summary
- This technology describes a class of chemical compounds that specifically modulate cellular ferroptosis to treat a range of excitotoxic disorders.
- Technology Benefits
- Ferroptosis offers a distinct pathway for the treatment of diseaseSmall molecule inhibitors are easily tuned through medicinal chemistry and inexpensive to produceDistinct cell death mode may provide insight into biological pathways and cell death regulation
- Technology Application
- Prevention of cell deathInhibition of non-standard cell death pathwaysSpecific targeting of tumorigenic cancer cellsProtection against neurodegenerative diseasesTreatment of a range of excitotoxic disorders
- Detailed Technology Description
- None
- *Abstract
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None
- *Inquiry
- Beth KaudererColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
- *IR
- CU12192
- *Principal Investigator
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- *Publications
- Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A, Stockwell BR. “Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models” J Am Chem Soc. 2014 Mar 26;136(12):4551-6.Tech Ventures Reference:IR CU12192Licensing Contact: Beth Kauderer
- Country/Region
- USA
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