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3-phosphoglycerate dehydrogenase (PHGDH) inhibitors
Detailed Technology Description
The inventors have identified inhibitors for an enzyme, PHGDH, that is required for the synthesis of serine, which can be used to treat certain cancers.
Others
Identification of a smallmolecule inhibitor of 3-phosphoglycerate dehydrogenase to target serinebiosynthesis in cancers. Mullarky et al., PNAS 2016.
Country/Region
USA
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