Drift-Free and Calibration-Free Measurement of Analytes
- Technology Benefits
- Calibration-free operation reduces the need for high precision fabrication Calibration-free operation reduces end user burden and costs Increased measurement reliabilityLong-duration measurements in complex media
- Technology Application
- Detection of a variety of targets including small molecules, ions, specific oligonucleotides and proteins in complex sample matrices, such as in the living body
- Detailed Technology Description
- Researchers at the University of California, Santa Barbara have created a method of achieving the calibration- and drift-free operation of voltammetric electrochemical biosensors. This approach can be used to determine absolute target concentrations without the need to calibrate the sensor. For the measurement of several drugs the errors between experimental values and estimated values are within 10% across broad concentration ranges. Additionally, this approach eliminates the baseline drift problem seen in complex media, such as in flowing, undiluted whole blood.
- Others
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Background
Existing electrochemical biosensor architectures all require calibration in order to correct for inter-sensor variation arising due to variation in fabrication and intra-sensor variation caused by drift in order to achieve accurate results. It would be advantageous to develop electrochemical biosensor platforms that work stably and autonomously over long periods of time even in complex environments (such as in vivo) without the need for end-user calibration.
Additional Technologies by these Inventors
- Fluorescent and Electrochemical DNA-Based Switches for Antibody Detection
- Bio-electrochemical Sensor for Real-time, In Vivo Clinical Tests
- Dual-Labeled E-AB Platform for Continuous, Real-Time Monitoring of Small Molecules
- Drift-Free, Self-Calibrated Interrogation Method For Electrochemical Sensors Based On Electron Transfer Kinetics
Tech ID/UC Case
28737/2017-607-0
Related Cases
2017-607-0
- *Abstract
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A method of achieving the calibration- and drift-free operation of voltammetric electrochemical biosensors.
- *Principal Investigator
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Name: Philippe Dauphin Ducharme
Department:
Name: Hui Li
Department:
Name: Gabriel Ortega Quintanilla
Department:
Name: Kevin Plaxco
Department:
- Country/Region
- USA
