Branched Arginine Based Poly(Ester Urea Urethane) Nanoparticles as Drug Delivery (Chemotherapeutic) Vehicles
- Detailed Technology Description
- Self-assembled nanoparticles (NPs) composed of linearand branched Arginine-based poly-ester urea urethanes (Arg-PEUUs) as carriersfor cancer treatments.
- Others
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1) Self-Assembled Cationic Biodegradable Nanoparticles from pHResponsive Amino-Acid-Based Poly(Ester Urea Urethane)s and Their Application Asa Drug Delivery Vehicle. Mingyu He et.al. Biomacromolecules2016, 17, 523−537.
2) Folate-decorated arginine-based poly(ester urea urethane)nanoparticles as carriers for gambogic acid and effect on cancer cells. He M, RoL, Liu J, Chu C-C. J. Biomed. Mater. Res., 2017, 105, 475-490.
- *Abstract
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Theseself-assembled nanoparticles are easily prepared by a facile dialysis method.Their assembly is directed by a combination of hydrophobic/hydrophilicinteractions. By varying the ratio of polymer as well as varying functionalgroups, the size of the nanoparticles (100-300 nm) as well as their mechanicaland hydrophobic properties can be finely tuned. Likewise, photoactive groupssuitable for crosslinking can be included to further enhance nanoparticlestability. Even prior to drug loading these nanoparticles enhance macrophage production of TNF-α and nitric oxide.
These nanoparticles can be loaded with a variety ofchemotherapeutic agents including doxorubicin(DOX) and gambogic acid (GA). In vitro studies performed withGA-loaded nanoparticles, a low solubility chemotherapeautic, showed 80-90%release within 60h. Additional studies show that external folate functionalizationcan be added to the nanoparticle to enhance cell attachment and facilitate internalizationthereby improving the anti-cancer drug potency. Further in vivo studies on MCF-7 (invasive breast ductal carcinoma)xenograft mice show promising results.
Potential Applications
· Drug Delivery
· Targeted Chemotherapy
Advantages
· Can be neutral or cationic allowing variousmethods of introduction into targeted cell.
· Can be used in 3D-printing. (Dissolvable in lowboiling solvents)
· High degree of biocompatibility andbiodegradability in mammalian cells
· Prepared by a facile dialysis method
- *Licensing
- Martin Teschl, Technology Commercialization & Liaison Officermt439@cornell.edu(607) 254-4454
- Country/Region
- USA
