Patient-specific aptamer generation for sensitive and noninvasive diagnosis of minimal residual disease
- Summary
- This technology is a microfluidic device that generates aptamers for individualized detection of minimal residual disease (MRD).
- Technology Benefits
- Highly sensitive and specific technique for MRD detection and diagnosisNoninvasive diagnostic method, requires only a blood draw Low-cost diagnostic toolCan be used for frequent screening (e.g., every 2-4 weeks) and early detection of cancer relapse
- Technology Application
- Generation of personalized aptamers that detect the presence of M-proteins and MRDGeneration of aptamers against other biomarkers of disease, particularly other blood cancersDiagnostic tool for point-of-care treatmentPlatform for personalized diagnostics
- Detailed Technology Description
- None
- *Abstract
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None
- *Inquiry
- Richard NguyenColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
- *IR
- CU15020
- *Principal Investigator
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- *Publications
- Olsen T, Zhu J, Kim J, Pei R, Stojanovic MN, Lin Q. "An integrated microfluidic SELEX approach using combined electrokinetic and hydrodynamic manipulation" SLAS Technol. 2017 Feb; 22(1): 63-72.Kim J, Olsen T, Zhu J, Hilton J, Yang K, Pei R, Stojanovic M, Lin Q. “Integrated Microfluidic Isolation of Aptamers Using Electrophoretic Oligonucleotide Manipulation” Scientific Reports. 2016 May 24; 6: 26139.Tech Ventures Reference:IR CU15020Licensing Contact: Richard Nguyen
- Country/Region
- USA
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