Regulation Of Tumor-Associated T-Cells
- Technology Application
- Cancer treatmentRegenerative medicineImmunotherapy
- Detailed Technology Description
- Identification of a novel cell type that appears to play a role in the T cell therapy of cancer
- *Abstract
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The invention relates to the use of ex vivo expandedtumor-infiltrating lymphocytes (TILs) as a potential treatment modality forcancer. It further details compositions of these TILs between patients and howthis relates to prognosis and methods for improving TIL expansion and functionfor the treatment of cancer.
We have identified a novel regulatory cell type, innate lymphoidcells (ILC), that appear to impact TILs. Specifically, administering to thepatient a therapeutically effective amount of a compound that decreases thesuppressive effect of ILCs can have an impact on tumor infiltrating lymphocyte(TIL) propagation, expansion or function.
- *Principal Investigator
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Drs.SarahCrome and Pamela Ohashi,University Health Network
- *Publications
- Crome, S.Q. et al. A distinct innate lymphoid cell population regulates tumor-associated T cells. Nat Med. 2017 Mar;23 (3):368-375.
- Country/Region
- USA
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