Quantitative Endoscopy for Improved Target Delineation in Planning Intensity Modulated Radiation Therapy for Head and Neck Cancer
- Technology Application
- Radiation treatment planning, brachytherapy delivery
- Detailed Technology Description
- Endoscopy-Enhanced RadiationTherapy Planning and Visualization
- *Abstract
-
This technology enables the integration of clinicalendoscopy examinations into radiation therapy planning and response assessment. 2D optical and 3D CT image sets areco-registered by tracking and registering the coordinates of an endoscoperelative to the planning CT image set.
From here, users can perform several functions,including contouring on 2D images and display 3D dose levels on real-time videoimages. For many cancers, for instance,head and neck, esophagus, bladder, etc., superficial margins are often moreclearly defined in the 2D optical image. With our system, users can contour lesionsvisible on the 2D image. These regions of interest are projected onto the 3D CTplanning image, generating a 3D ROI that can be exported in a format compatiblewith any standard clinical treatment planning software.
For treatment response assessment, the system can importradiation dose from the treatment planning system. The dose can then bedisplayed on top of live 2D video, enabling the clinician to compare treatmentresponse, such as tumor regression or normal tissue toxicities, to thedelivered dose. This is an especially attractive feature for examinations ofradiation proctitis following prostate treatments, and mucositis following headand neck treatments. Current testing onphantoms demonstrates a registration accuracy of ±1mm.
- *Principal Investigator
-
R. Weersink, D. Jaffray, J. Irish,A. Hope, et. al., University Health Network
- *Publications
- R.A. Weersink et al: Improving SuperficialTarget Delineation in Radiation Therapy with Endoscopic Tracking andRegistration, Med. Phys, 38(12): 6458-6468, 2011.J. Qiu et al: Displaying 3D radiation dose onendoscopic video for therapeutic assessment and surgical guidance, Phys. Med.Biol, 57(20): 6601-6614, 2012.E. Chamma et al:Optically-tracked handheld fluorescence imaging platform for monitoring skinresponse in the management of soft tissue sarcoma. Journal of Biomedical Optics,2015. 20(7).
- Country/Region
- USA
