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Probiotics Expressing GLP-1 as an Aid to prevent or Treat Diabetes

Detailed Technology Description
The technology provides recombinant cells and methodsusing commensal bacteria for the prevention and treatment of diabetes ormetabolic syndromes.
Others
  • Patents issued in the U.S. 8,771,668 (D-4291) and 9,265,842 (D-5208)
  • Patents issued in the Europe EP2274416 (D-4291) and EP2627770(D-5208)
  • Duan, F., Curtis, K. L. and March, J. C. (2008).Secreting insulinotropic proteins from commensal bacteria: rewiring the gut totreat diabetes. Applied and Environmental Microbiology, 74: 7437-7438
  • Duan,F., Liu, J. H. and March, J. C. (2015). Engineered commensal bacteria reprogram intestinal cells intoglucose-responsive insulin-secreting cells for the treatment of diabetes.  Diabetes, 64: 1794-1803.

  
*Abstract

The humangastrointestinal (GI) tract is home to hundreds of bacterial species requiredfor normal metabolism. Commensal bacteria in the GI tract coexist with theirhuman hosts and with each other through a complex system of checks and balances.

 

The FDA considerscommensal bacteria safe, having already approved them as food supplements.Commensal bacteria have great potential as a drug delivery vehicle, both aspreventive means for bacterial diseases and as replacement therapy fordiseases.

 

A team at Cornellhas engineered commensal bacteria that express the protein of interest GLP-1when triggered by glucose.  GLP-1activates insulin synthesis in pancreatic β cells by binding to the membranereceptor GLP-1R.

 

Here, the teamrelies on the fact that intestinal epithelial cells convert intoinsulin-secreting cells when induced by GLP-1. This finding paves the way for new therapeutic approach to insulindependent diabetes through the gut.

 

Potential Applications

Probioticsas aid in the treatment of diabetes.

 

Advantages

  • Compatibility of commensal strains with the human host
  • Simple oral dosing
  • No significant background expression
  • Persistence of the strain in the gut
  • May even eliminate the need for insulin injection
  • Allows for delivery of GLP-1 to intestinal membrane.

  
*Licensing
Jeff Fearnjcf55@cornell.edu607-254-4502
Country/Region
USA

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