AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.

Back to search results

Predicting and Treating Cancer Metastasis Before the Formation of Pre-metastatic Clusters

Detailed Technology Description

This invention provides a method of predictingcancer metastases by monitoring VEGFR1+ bone marrow derived cells(BMDCs) in cancer patients and a method of inhibiting and treating tumormetastasis by preventing the formation of pre-metastatic clusters of VEGFR1+BMDCs at the site distant from the primary site.

Others

IssuedUS Patent 7,598,043.
IssuedUS Patent 8,465,738.
VEGFR1-positive haematopoietic bone marrowprogenitors initiate the pre-metastatic niche. Nature, 2005, 438,820-7.
News and Views. Cancer biology: emissaries set upnew sites. Nature, 2005, 438, 750-1.
Migratory neighbors and distant invaders:tumor-associated niche cells. Genes Dev, 2008,22, 559-74.
Bone marrow cells in the 'pre-metastatic niche':within bone and beyond. Cancer MetastasisRev. 2006, 25, 521-9.
Preparing the "soil": the premetastaticniche. Cancer Res, 2006, 66, 11089-93.
Niche-to-niche migration of bone-marrow-derivedcells. Trends Mol Med, 2007,13, 72-81.

Country/Region

USA

For more information, please click Here