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Novel Immunocompetent Breast Cancer Mouse Model

Summary: Purdue University researchers found the receptor tyrosine kinase EphA2 is over-expressed in breast cancer cells, and therefore, provides a unique target for breast cancer intervention. An immunocompetent mouse model of breast cancer has been developed for evaluating various therapeutic approaches including those involving activation or inhibition of EphA2.

Technology Benefits: Improved mouse model of breast cancer

Technology Application: Drug development Therapy evaluation

Detailed Technology Description: Suresh MittalPurdue Comparative Pathobiology

*Abstract

*Background: Various monoclonal antibody-based treatments for breast cancer exist at different stages of development. Present technologies utilize the nude mouse model of breast cancer, which is not a true reflection of what may occur in normal animals in response to such treatments.

*Stage of Development: Prototype validation and trial production

*Web Links: Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipSuresh MittalPurdue Comparative Pathobiology

Country/Region: USA

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