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Isolation of Adenovirus E1 Expressing Cell Lines and Strategies to Generate Adenovirus Recombinants

Summary: Purdue University researchers have developed a technique for isolating cell lines with desired characteristics in the cell lines expressing adenovirus E1. Following adenovirus infection of a cell, E1 genes are the first viral genes expressed and are essential for virus replication. Therefore, the generation and growth of E1-deleted adenoviral vectors is possible only in a cell line that constitutively expresses E1 proteins. This technology involves the isolation of a number of cell lines expressing either human adenovirus (HAd) or bovine adenovirus (BAd) E1 genes. These isolated cell lines may be useful in generating and replicating adenovirus recombinants for vaccination and gene therapy applications.

Technology Benefits: Better cell lines for propagating E1-deleted HAd or BAd Simple generation of cell lines with specific characteristics

Technology Application: Gene therapy Vaccines Drug delivery

Detailed Technology Description: Suresh MittalPurdue Comparative Pathobiology

*Abstract

*Stage of Development: Prototype validation and trial production

*Web Links: Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipSuresh MittalPurdue Comparative Pathobiology

Country/Region: USA

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