Raman Macro Imaging System for Fast Biocompatible Tissue Characterization
- Technology Benefits
- High resolution and high sensitivity, with ~1cm penetration depthNon-invasiveNon-ionizing and non-radioactiveCost-effective
- Technology Application
- It can be used to replace expensive tissue imaging systems and diagnose various tissue abnormalities, including heterotopic ossification, which can arise from complications due to wounds, bone surgery, amputation, and brain or spinal cord surgeries.
- Detailed Technology Description
- This technology includes a real time optical imaging system that can detect bone and early stages of bone formation in flesh by a unique optical Raman signature. It is based on Raman spectroscopy, a powerful technique that can detect substances by providing information on the bonds and their structure within the material. This technology captures two direct tissue images in different wavelengths with a CCD camera and LEDs as an illumination source. A subtraction of these two images reveals only the unique Raman signals and therefore an intensity map of bone locations can be created, where tissue abnormality can then be detected.
- Others
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State Of Development
Researches have acquired initial results that serve as a proof of concept on the feasibility and biocompatibility of the proposed Raman imaging system.
Background
Bone growth in flesh is an undesirable outcome that occurs in open wounds where trauma to the limb is severe, causing the wound to fail and ultimately lead to amputation. Early detection is crucial in failed wounds. However, current technologies, including X-ray and MRI, are limited and do not offer the resolution and sensitivity that is required in such cases. In addition, the resulting radiation dose from these systems is undesirable, as they can be harmful to patient health. These methods are also very expensive. Therefore, an alternative method is needed.
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Tech ID/UC Case
25025/2014-598-0
Related Cases
2014-598-0
- *Abstract
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UCLA researchers in the Department of Electrical Engineering have developed a novel optical imaging system to detect early stages of abnormal bone formation in flesh.
- *Principal Investigator
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Name: Warren Grundfest
Department:
Name: Asael Papour
Department:
Name: Oscar Stafsudd
Department:
Name: Zachary Taylor
Department:
- Country/Region
- USA
