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Wnt1 for the Treatment of Peripheral Vascular Disease and the Repair of Heart

Technology Benefits
This is the first time that the role of Wnt1 in enhancing cardiac repair after acute cardiac injury has been described and demonstratedIt has been demonstrated that Wnt1 can also enhance function of human endothelial progenitors
Technology Application
Can be used as a novel therapy for cardiac repair after acute cardiac injury Can be used as a therapeutic agent to increase blood flow to ischemic extremities Can be used to enhance the function of endothelial progenitor cells prior to cell based therapy in clinical trials
Detailed Technology Description
Dr. Arjun Deb and colleagues in the Department of Medicine have demonstrated that Wnt1 is an agent critical for cardiac repair. After acute cardiac injury, Wnt is expressed in the epicardium of the heart and cardiac fibroblasts, and orchestrates a critical early repair response. Interruption of downstream Wnt signaling leads to the development of heart failure and death within a few days of injury. In addition, the researchers discovered that Wnt1 can also enhance human endothelial progenitor function.
Application No.
9186388
Others

State Of Development

Researchers have experimentally demonstrated the physiological role and therapeutic effect of Wnt1 in the treatment of cardiovascular disease.

Background

Heart disease is a leading cause of mortality and morbidity and an emerging public health problem in the developing world. The inability of the mammalian heart to regenerate cardiac muscles after acute myocardial injury remains a fundamental biological problem to the therapy of heart disease. Therefore, there is a clear need for novel therapeutic strategies.

Related Materials

Duan, Jinzhu, et al. "Wnt1/beta-catenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair." The EMBO journal 31.2 (2012): 429-442.


Additional Technologies by these Inventors


Tech ID/UC Case

24785/2013-782-0


Related Cases

2013-782-0
*Abstract
UCLA researchers in the Department of Medicine have developed a novel therapeutic agent for cardiac repair after acute cardiac injury.
*Applications
  • Can be used as a novel therapy for cardiac repair after acute cardiac injury 
  • Can be used as a therapeutic agent to increase blood flow to ischemic extremities 
  • Can be used to enhance the function of endothelial progenitor cells prior to cell based therapy in clinical trials
*IP Issue Date
Nov 17, 2015
*Principal Investigator

Name: Arjun Deb

Department:

Country/Region
USA

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