Graphene Based Catalysts for Biomimetric Generation of Antithrombotic Species

The reported conjugate molecule is intended for incorporation into polymeric coatings, for application in cardiovascular implants (e.g. stents) and surgical tools (e.g. catheters).

Professor Duan and colleagues have devised a graphene-based conjugate tandem catalyst that catalyzes the formation of nitric acid (HNO), a well-known reducer of blood clots, from internal glucose and the amino acid L-arginine. Nitric acid has been recognized as a potent antithrombotic agent but related materials suffer from a short life time. Successful design and utilization of HNO for biomedical applications remains challenging. UCLA researchers developed a graphene-hemin-glucose oxidase conjugate as a tandem catalyst. The graphene scaffolding successfully supports the glucose oxidase as it locally catalyzes the production of peroxide in the blood. Endogenous and readily abundant glucose and L-arginine produce HNO that acts to prevent blood clotting. The graphene conjugate tandem can be applied as a coating onto biomedical devices. Antithrombotic properties can be added onto catheters, vascular grafts, heart valves, and biosensors.

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Background

Blood clotting (thrombosis) is a major risk associated with cardiovascular surgeries and implants. Nitric oxide (NO) is a natural anti-clotting agent, but materials using NO for ant-clotting purposes offer a very short functional life. Nitroxyl (HNO) offers comparable anti-clotting properties with a longer functional life but has not previously been employed by anti-clotting materials.

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Tech ID/UC Case

24568/2014-521-0

Related Cases

2014-521-0

USA