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Magnetic Actuation of Nanoparticles for Noninvasive Remotely-Controlled Release of Drug

Technology Benefits: To date no other components condensed within MSNs have been used for remote heating and delivery of materials. The selectivity and non-invasiveness of this technique marks an improvement over current drug delivery systems particularly for in vivo applications. In terms of cancer cell treatments, this model combines two known chemotherapies to produce one that is more potent.

Technology Application: While this technology is currently beneficial in a laboratory environment for delivering drugs or dyes to non-biological systems or in vitro cell lines, its in vivo applications especially for treatment of cancer also bears enormous feasibility.

Detailed Technology Description: When placed in an AC magnetic field, zinc NCs encapsulated within an MSN core can generate a large amount of local internal heating, causing molecular machines (nanovalves) on the MSN surface to disassemble and permit cargo release. Therefore, at biological temperatures, cargo (drug) can be contained until it is selectively dispensed to target cells or tissues. In testing this, researchers discovered that the cumulative effect of drug and hyperthermia from zinc NCs had a more potent impact on apoptosis of an in vitro cancer cell line than either treatment in isolation. Thus, while this technology has broad applications as a well-controlled, remote method for administration of therapeutic agents it also has been verified for its potential as an effective cancer treatment as well.

Supplementary Information: Patent Number: US20130046274A1
Application Number: US13550374A
Inventor: Zink, Jeffrey I. | Thomas, Courtney R. | Liong, Monty | Henscheid, Sarah Angelos | Cheon, Jinwoo | Lee, Jae-Hyun | Ferris, Daniel P.
Priority Date: 14 Jul 2011
Priority Number: US20130046274A1
Application Date: 16 Jul 2012
Publication Date: 21 Feb 2013
IPC Current: A61M0005168 | B82Y000500
US Class: 604500 | 604113 | 977773 | 977904
Assignee Applicant: The Regents of the University of California
Title: METHOD OF CONTROLLED DELIVERY USING SUB-MICRON-SCALE MACHINES
Usefulness: METHOD OF CONTROLLED DELIVERY USING SUB-MICRON-SCALE MACHINES
Summary: The method is useful for controlled delivery of a substance including anticancer drug such as doxorubicin into a human body for treating cancer, where the substance further includes a cosmetic-, a therapeutic-, a nutritional-, or a diagnostic agent (all claimed). No biological data given.
Novelty: Method for controlled delivery of substance into body, comprises administering containment vessels into the body, and providing time-varying magnetic field to cause release of substance from the containment vessels

Industry: Disease Diagnostic/Treatment

Sub Category: Cancer/Tumor

Application No.: 20130046274

Others

State Of Development

Thus far these methods have been tested successfully in vitro and testing in biological settings is currently underway.

Background

Mesoporous silica nanoparticles (MSNs) are non-toxic, endocytoseable nanomaterials that may be used to carry and mediate release of cargoes such as drugs to targeted tissues and cells. A vast array of methods from pH to light have been used to control the nanovalves on the particles that trap and release cargos within the pores. Magnetic nanocrystals (NCs) have previously been used in biomedical applications both for their usefulness in inducing hyperthermic effects when placed in a magnetic field and for their MRI imaging capabilities. Zinc-doped iron oxide NCs are particularly well-suited for these purposes. The combination of these two technologies yields a novel approach to drug delivery whereby zinc NCs are used to actuate MSN cargo distribution.

Additional Technologies by these Inventors

Tech ID/UC Case

22125/2010-976-0

Related Cases

2010-976-0

*Abstract: Researchers at UCLA have developed a novel system that combines mesoporous silica nanoparticles with magnetic nanocrystals as a thermally sensitive means of delivering drugs to targeted cells. The synergistic effect of these materials in providing both heat and drug make this method especially significant as a non-invasive, externally controlled drug delivery system with cancer killing potential.

*IP Issue Date: Feb 21, 2013

*Principal Investigator: Name: Sarah Henscheid
Department:

Name: Jinwoo Cheon
Department:

Name: Daniel Ferris
Department:

Name: Jae-Hyun Lee
Department:

Name: Monty Liong
Department:

Name: Courtney Thomas
Department:

Name: Jeffrey Zink
Department:

Country/Region: USA

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