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pH-Responsive Nanovalves for On-Demand Release of Guest Molecules

Technology Benefits

Operates in aqueous media (physiological condition)Responds to low pHConsists of pseudorotaxane molecules

Technology Application

On-demand release of anticancer drug in cancer therapyOn-demand release of anti-microbial drugs in dental treatmentOn-demand release of anti-viral drugs in agriculture

Detailed Technology Description

Researchers at UCLA have invented a novel pH-responsive nanovalve system that employs biocampatible components, relies on ion-dipole interactions, and operates in aqueous media. This was achieved by filling a tiny, porous silica sphere with a drug and then plugging the pores with the valves. Applying this system, researchers can use pH changes to control a drug's release. Current nanovalves can open in locations where low pH conditions occur, such as in the lysosome of a cell, or in the acidic environment of the stomach.

Supplementary Information

Patent Number: US20100310465A1
Application Number: US2010841331A
Inventor: Zink, Jeffrey I. | Lu, Jie | Tamanoi, Fuyuhiko | Nel, Andre | Angelos, Sarah | Stoddart, Fraser | Chen, Qiaolin | Xia, Tian | Patel, Kaushik | Dichtel, William
Priority Date: 23 Jan 2008
Priority Number: US20100310465A1
Application Date: 22 Jul 2010
Publication Date: 9 Dec 2010
IPC Current: A61K000914 | A61K0031352 | A61K004900 | A61P000702 | A61P000912 | A61P002508 | A61P002702 | A61P002900 | A61P003112 | A61P003500 | A61P003706 | A61P003906 | B01J001900
US Class: 4240091 | 422105 | 424489 | 514454 | 977724
Assignee Applicant: The Regents of the University of California
Title: NANO-DEVICES HAVING RELEASABLE SEALS FOR CONTROLLED RELEASE OF MOLECULES
Usefulness: NANO-DEVICES HAVING RELEASABLE SEALS FOR CONTROLLED RELEASE OF MOLECULES
Summary: For administering at least one of biologically active substance, therapeutic substance, neutraceutical substance, cosmetic substance or diagnostic substance (claimed).
Novelty: Nanodevice to administer therapeutic comprises device with storage vessel and port(s); and stopper with blocking unit at port(s), responsive to predetermined catalytic stimulus, so that blocking unit is released to release stored material

Industry

Biomedical

Sub Category

Medical Device

Application No.

20100310465

Others

State Of Development

The invention has been validated in aqueous solutions.

Background

Neuropathic pain is a type of chronic pain caused by the dysfunction of one or more nerves. This type of pain represents a challenge in medicine because of its frequency, severity, and limited number of effective treatment options. In the USA and European countries, the prevalence of neuropathic pain is between 1.5 and 7.7% of the population. Most patients respond poorly to standard pain therapies involving pain killers. One treatment that has been used to reduce neuropathic pain is antidepressants. Antidepressants are useful, however the mechanisms are unknown and they have unwanted side effects. Therefore, there is a need to uncover how antidepressants work in neuropathic pain, which would then open up new targets to design better analgesics.

Related Materials

"Nanovalve for Drug Delivery". by Jocelyn Rice. Technology Review. March 13, 2008
"US team claims a first in nanovalves for drug delivery". in-Parma Technologist.com. March 19, 2008.
"Nano Targeted Drug Delivery". by Asaf Peer. The Future of Things. July 14, 2008

Additional Technologies by these Inventors

• Mesoporous Silica Nanoparticle Based siRNA/Drug Delivery System
• Magnetic Actuation of Nanoparticles for Noninvasive Remotely-Controlled Release of Drug

Tech ID/UC Case

21559/2008-374-0

Related Cases

2008-374-0

*Abstract

UCLA inventors have developed novel nanovalves that aid in the release of guest molecules, such as anticancer drugs, in response to pH levels.

*Applications

• On-demand release of anticancer drug in cancer therapy
• On-demand release of anti-microbial drugs in dental treatment
• On-demand release of anti-viral drugs in agriculture

*IP Issue Date

Dec 9, 2010

*Principal Investigator

Name: Sarah Henscheid

Department:

Name: Qiaolin Chen

Department:

Name: William Dichtel

Department:

Name: Jie Lu

Department:

Name: Andre Nel

Department:

Name: Kaushik Patel

Department:

Name: James Stoddart

Department:

Name: Fuyuhiko Tamanoi

Department:

Name: Tian Xia

Department:

Name: Jeffrey Zink

Department:

Country/Region

USA