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Male Mice Lacking Sry on the Y Chromosome with a Function Autosomal Sry Transgene

Technology Benefits: New candidate pathwaysBetter understanding on the mechanism of action for antidepressantsSimple and convenient assay that may be used in high throughput format

Technology Application: This mouse strain allows investigation of the separate actions, and interactions, of different types of sex-specific forces (hormonal and chromosomal) that cause sex differences.

Detailed Technology Description: UCLA researchers have developed mice in which the Sry gene is deleted from the Y chromosome and inserted onto an autosome as a transgene, effectively transferring testis determination from the Y chromosome to an autosome. When male mice carrying the Sry transgene are mated to wild-type females, they produce four "core" genotypes that can be used as a model to investigate relationships between sex chromosome complement (XX or XY) and gonadal type that influences phenotypic characteristics.

Others: Related Materials
Chen X, et al. Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes. Dev Neurobiol. 2008 Feb 1;68(2):265-73.
Additional Information on Mouse Strain #010905 from The Jackson Laboratory

Tech ID/UC Case
21499/2010-496-0

Related Cases
2010-496-0

*Abstract: None

*Applications

This mouse strain allows investigation of the separate actions, and interactions, of different types of sex-specific forces (hormonal and chromosomal) that cause sex differences.

*Principal Investigator: Name: Arthur Arnold
Department:

Country/Region: USA

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