Multivalent Targeting Strategy for Drug Carriers
- Technology Benefits
- Enhanced targeting of the cell type of interest Non-viral approach Potential to take any drug carrier particle and modify with multivalent ligands Modified drug carriers are more sensitive to receptors on the targeted cell surface
- Technology Application
- Increase the targeting efficiency and specificity of drug carriers towards targeted cells by using multivalent ligand binding Potential uses for drug delivery and imaging applications Potential that any drug carrier particle can be modified by this technique to enhance its targeting and efficacy
- Detailed Technology Description
- Researchers at UCLA have identified a multivalent targeting strategy that increased the targeting efficiency and specificity of drug carriers toward targeted cells. This strategy involves spatially constraining ligands, so that the ligands are presented as clusters rather than single molecules. The method involves the modification of DNA loaded nanoparticles with the ligand clusters. This type of an approach has been shown to be more effective at targeting cancer cells with high expressions of integrin receptors and more effective at delivering genes compared to drug carriers with homogeneously distributed ligands. Because of the enhanced targeting and gene transfer efficiency, it is believed that this approach is ideal for the delivery of nucleic acid based drugs.
- Supplementary Information
- Patent Number: US8263133B2
Application Number: US2010708520A
Inventor: Segura, Tatiana | Ng, Quinn
Priority Date: 18 Feb 2009
Priority Number: US8263133B2
Application Date: 18 Feb 2010
Publication Date: 11 Sep 2012
IPC Current: A61K000914 | A61K003800 | A61K004800 | C12N001511
US Class: 424489 | 514044A | 514044R | 530300 | 977773
Assignee Applicant: The Regents of the University of California
Title: Multivalent clustering targeting strategy for drug carriers
Usefulness: Multivalent clustering targeting strategy for drug carriers
Summary: The method is useful for treating a disease state. The disease state is cancer selected from breast cancer, gastric cancer, bladder cancer, ovarian cancer, thyroid cancer, lung cancer, prostate cancer, uterine cancer, testicular cancer, neuroblastoma, glioblastoma, squamous cell carcinoma of the head, neck, cervix and vagina, multiple myeloma, lymphoma, leukemia, or soft tissue and osteogenic sarcoma (all claimed).
Novelty: Treating a disease state, e.g. cancer, by targeting a nucleic acid therapeutic agent to a target expressing a receptor comprises contacting the target with a composition comprising nanoparticles modified with ligands
- Industry
- Disease Diagnostic/Treatment
- Sub Category
- Cancer/Tumor
- Application No.
- 8263133
- Others
-
State of Development
Inventors have demonstrated their strategy in vitro using RGD and DNA/PEI polyplexes.
Background
Ligand binding to the surface of drug carriers has been explored as a way of enhancing targetability and overall efficiency of drug delivery and imaging applications. Multivalent binding to imaging agents has been investigated and has been demonstrated to increase targeting over monovalent binding. However, multivalent ligand binding to enhance targeting of drug-loaded nanoparticles has not been investigated. Therefore, there is a need to investigate the effect of multivalent binding to drug-loaded nanoparticles.
Related Materials
Protein-polymer nanoparticles for nonviral gene delivery. Biomacromolecules (2011).
Additional Technologies by these Inventors
- Novel Method to Spatially Program Stem Cell Fate
- Multi-Arm Block-Copolymers for Multifunctional Self-Assembled Systems
Tech ID/UC Case
20357/2009-233-0
Related Cases
2009-233-0
- *Abstract
-
UCLA investigators developed a multivalent targeting strategy to modify drug carriers and enhance its targetability, sensitivity, and overall efficiency. This method involves the modification of drug-loaded nanoparticles, and has potential uses for drug delivery, imaging and medical applications.
- *IP Issue Date
- Sep 11, 2012
- *Principal Investigator
-
Name: Quinn Kwan Tai Ng
Department:
Name: Tatiana Segura
Department:
- Country/Region
- USA
