Stem Cell Urinary Tract Reconstruction Therapy
- Technology Benefits
- Human adipose tissue is abundant, can be maintained in vitro for extended periods, can be easily obtained with minimal discomfort to the patient, and can be maintained in vitro for extended periods No ethical or political considerations
- Technology Application
- Harvest stem cells from adipose tissue and differentiate them into functioning smooth muscle cells Utilize adipose derived stem cells for reconstruction or tissue engineering of smooth muscle containing organs Use developed delivery methods to deliver adipose derived stem cells into smooth muscle layer of the urinary tract
- Detailed Technology Description
- UCLA researchers have successfully induced the differentiation of adipose derived stem cells into contractile smooth muscle cells. Researchers have also developed ways to deliver these cells into the smooth muscle layer of the urinary tract (bladder and urethra). These adipose derived stem cells can be used for the reconstruction of the urethra in the treatment of urinary stress incontinence and for reconstruction of the bladder in conditions such as neurogenic bladder, bladder augmentation, and bladder extrophy.
- Supplementary Information
- Patent Number: US7531355B2
Application Number: US2005192753A
Inventor: Rodríguez, Larissa V. | Wu, Ben
Priority Date: 29 Jul 2005
Priority Number: US7531355B2
Application Date: 29 Jul 2005
Publication Date: 12 May 2009
IPC Current: C12N000500 | C12N00050775
US Class: 435377 | 435325 | 435375
Assignee Applicant: The Regents of the University of California
Title: Methods and compositions for smooth muscle reconstruction
Usefulness: Methods and compositions for smooth muscle reconstruction
Summary: The compositions and methods are useful for inducing leiomyogenic differentiation of a purified ADSC, reconstituting leiomyogenic cells in vivo , treating incontinence in a subject, treating stress incontinence in a subject, alleviating the symptoms of bladder disease, and assaying for modulation of smooth muscle contractile response (claimed). The compositions can also be used for treating vascular disorders, intestinal disorders, vesicoureteral reflux, or other disorders of smooth muscle function.
Novelty: New composition comprises purified adipose-derived stem cell (ADSC), and laminin or heparin, useful for inducing leiomyogenic differentiation, and for treating stress incontinence in a subject
- Industry
- Biomedical
- Sub Category
- Pathogen
- Application No.
- 7531355
- Others
-
State Of Development
Stem cells have been harvested from human and animal adipose tissues and successfully induced to differentiate into smooth muscle cells.
Background
Urinary incontinence (UI) and stress urinary incontinence (SUI) are medical and social conditions that greatly erode ones quality of life. These conditions are embarrassing and cause significant hospitalization. There is a great prevalence of UI in women of all ages (13 million), and approximately 50% of all incontinent women are classified as having SUI. SUI is caused by the loss of anatomic support and/or atrophy and dysfunction of the sphincteric mechanism of the urethra. This loss of support and/or atrophy then results in involuntary urine loss during any activity that causes abdominal straining (i.e. laughing, coughing, and sneezing). One of the current treatments for SUI involves injecting bulking materials into the urethral tissues. However, multiple injections are required, cure rates are low, and there are significant problems with material loss and migration. Treatments of bladder conditions and bladder substitution involve attempts at urinary tract reconstruction, using mature smooth muscle cells obtained from the host. The procurement process is morbid, and only small amounts of cells are obtained. Thus, there is a need for a better curative treatment that can improve the quality of life of these patients.
Related Materials
Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction. J Urol. (2005)
Urinary bladder smooth muscle engineered from adipose stem cells and a three dimensional synthetic composite. Biomaterials. (2009)Tech ID/UC Case
20293/2004-084-0
Related Cases
2004-084-0
- *Abstract
-
Researchers from the UCLA Department of Urology have successfully harvested stem cells from adipose tissue and differentiate them into functioning smooth muscle cells. These adipose derived stem cells can then be used for reconstruction or tissue engineering of smooth muscle containing organs, especially the urethra to treat urinary and stress incontinence.
- *IP Issue Date
- May 12, 2009
- *Principal Investigator
-
Name: Larissa Rodriguez
Department:
Name: Benjamin Wu
Department:
- Country/Region
- USA
