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Production of Malarial Surface Proteins in Algae for Use as Transmission Blocking Vaccine Candidates

Detailed Technology Description: None

Application No.: 9422347

Others: State Of Development
Proof of concept: Multiple proteins have been produced in algal chloroplasts. Two have been tested and demonstrated correct folding and present the authentic antigen.

Related Materials
Steps toward a globally available malaria vaccine: harnessing the potential of algae for future low cost vaccines. Mayfield SP and Jones CS; Bioengineered 2013 May-June: 4(3) 164-7 PMID: 23090388

Tech ID/UC Case
23648/2011-360-0

Related Cases
2011-360-0

*Abstract: P. falciparum surface proteins have been shown to block transmission of malaria. Producing them in algae results in proteins that are correctly folded and not glycosylated, so they are more similar to the native proteins than those produced in bacterial or mammalian systems. In order to produce them for use as vaccine candidates, they will need to be produced in an inexpensive expression system that does not require much, if any, post-production modification and algae chloroplasts provide a viable approach.
SAMPLE DATA

*IP Issue Date: Aug 23, 2016

*Principal Investigator: Name: Michael Hannon
Department:

Name: Stephen Mayfield
Department:

Name: James Gregory
Department:

Name: Carla Jones
Department:

Country/Region: USA

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