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Porous Silicon Particles as Adjuvant to Modulate Immune Response and Deliver Antigens for Vaccination

Detailed Technology Description

UC San Diego researchers have developed porous silicon nano/micro-particles for use as adjuvants to more effectively modulate immune responses and deliver antigens for vaccination. For example, avidin was physically incorporated into porous Si nanoparticles, then anti-CD40 antibody conjugated with the nanoparticles through avidin-biotin interaction. CD40 is a costimulatory protein found on antigen presenting cells (APCs) and is required for their activation. In the invention, the porous Si nanoparticle construction is significantly more potent in stimulating APCs than free standing anti-CD40 antibody in vitro. APCs targeting protein with antigen can also be co-incorporated into porous Si nanoparticles together with anti-CD40 antibody to form “porous Si NanoVaccine.” Use of the constructed porous Si NanoVaccine can induce an immunity memory towards the given antigen. Multiple antigens and costimulatory molecules can be incorporated simultaneously into the porous Si NanoVaccine. Further, the intrinsic photoluminescence of porous Si nanoparticles allows for in vivo tracking. The invention could potentially enable utilizing the self immune system to treat diseases.

Supplementary Information

Inventor: Pang, Mingfang
Priority Number: US8056915B2
IPC Current: B62M000100 | B62M000124
US Class: 280221 | 280210 | 280220 | 280252 | 280256
Title: Stepping scooter
Usefulness: Stepping scooter
Summary: Treadle sliding vehicle.
Novelty: Treadle sliding vehicle has vehicle frame connected with treadle force drive device having treadle force drive mechanism and transmission accelerating mechanism, and drive wheel rotatably fixed on left side of main frame

Industry

Automotive

Sub Category

Vehicle Application

Application No.

9394369

Others

Intellectual Property Info

This technology has a patent pending and is available for licensing and sponsorship.

Tech ID/UC Case

21971/2011-164-0

Related Cases

2011-164-0

*Abstract

Modulating immune responses to pathogen invasion and tumors is a major goal in immunotherapy. Progress towards this goal can be accomplished by stimulating the immune response in vivo through active immunization. Biodegradable particles can be engineered for the purpose of improving immunization. Particulates can elicit potent immune responses, either by direct immuno-stimulation of antigen presenting cells or/and by delivering antigen to specific cellular compartments and promoting antigen uptake by appropriate stimulatory cell types. Micro- and nanoparticles derived from porous Si have been proposed as carriers to deliver external imaging and therapeutic but the immune response that may be triggered by functionalized silicon nanoparticles has thus far not been explored.

*IP Issue Date

Jul 19, 2016

*Principal Investigator

Name: Luo Gu

Department:

Name: Stephen Hedrick

Department:

Name: Zhengtao Qin

Department:

Name: Laura Ruff

Department:

Name: Michael Sailor

Department:

Country/Region

USA