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A Low Cost and Low Powered Integrated Cell-Sorting Module

Detailed Technology Description

UC San Diego researchers have invented a cell-sorting module that can be integrated with a flow-cytometry chip and system architecture for automated, closed-loop, cell detection and sorting. The invention provides a piezoelectrically actuated micro-sorter that operates at low power and low voltage and can deflect and sort single particles and cells at high speed. The micro-sorter can be added to existing microfluidic systems to perform cell sorting. To achieve closed-loop operation—with upstream fluorescence detection and downstream sorting—the invention provides algorithms for real-time signal processing and control. The invention presents, among others, the advantages of on-chip integration, automation with verification, low power operation, simple and low-cost fabrication, and small footprint.

Supplementary Information

Patent Number: US20120078531A1
Application Number: US13254851A
Inventor: Lo, Yu-Hwa | Chen, Chun Hao Randy | Cho, Sung Hwan | Tsai, Frank
Priority Date: 10 Mar 2009
Priority Number: US20120078531A1
Application Date: 28 Nov 2011
Publication Date: 29 Mar 2012
IPC Current: G06F001900 | G01N002100
US Class: 702021
Assignee Applicant: The Regents of the University of California
Title: FLUIDIC FLOW CYTOMETRY DEVICES AND PARTICLE SENSING BASED ON SIGNAL-ENCODING
Usefulness: FLUIDIC FLOW CYTOMETRY DEVICES AND PARTICLE SENSING BASED ON SIGNAL-ENCODING
Summary: Flow cytometry system for characterizing and analyzing molecule cluster and cells such as stem cell, circulating tumor cell and rare bacteria species, and for detecting and monitoring progression of disease such as acute myeloid leukemia (AML) and AIDS.
Novelty: Flow cytometry system for, e.g. analyzing e.g. molecule cluster, has particle detection module with encoder for producing and encoding different optical signals from light reflected from sample fluid in input fluidic channel

Industry

Disease Diagnostic/Treatment

Sub Category

Cancer/Tumor

Application No.

9134221

Others

Intellectual Property Info

This invention has a patent pending and is available for sponsored research and/or licensing.

Tech ID/UC Case

20011/2009-139-0

Related Cases

2009-139-0, 2010-144-1, 2010-145-1

*Abstract

Over the past decade, the field of microfluidics has begun to show great promise for research assays and diagnostics as well as for clinical applications. The field has evolved from devices comprised of simple microfluidic channels into complex devices that can mix fluids, pump liquids, perform digital logic, etc. Flow cytometry provides the field with a technology base from which both microfluidic and photonic components can be developed and integrated into a useful device.

*IP Issue Date

Sep 15, 2015

*Principal Investigator

Name: William (Will) Alaynick

Department:

Name: Chun Hao Randy Chen

Department:

Name: Sung Hwan Cho

Department:

Name: Sung Hwan Cho

Department:

Name: Kendall Chuang

Department:

Name: Nam Kim

Department:

Name: Yu-Hwa Lo

Department:

Name: Jose Morachis

Department:

Name: Frank Shangfeng Tsai

Department:

Country/Region

USA