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Chemically Amplified Response Strategies for Medical Sciences

Technology Benefits

Potential advantages from molecularly engineering linear dual-response mechanisms into the backbone of polymeric nanoparticles include enhanced stability and prolonged shelf life, while also increasing the response sensitivity and efficacy of targeted delivery to diseased environments. In addition, this polymeric nano-carrier technology may reduce overall toxicity by decomposing into easily excretable fragments. This technology is designed to be versatile where the triggering group can be sensitive to a number of wavelengths.

Detailed Technology Description

Researchers from UC San Diego have designed a new light-sensitive degradable polymer containing a quinone-methide, self-immolative moiety, which can be triggered to degrade through multiple light-sensitive groups. Nanoparticles formulated from this polymer are capable of releasing their molecule payload upon irradiation by UV and NIR light. The details of this technology are published in the patent application (2011/038117).

Supplementary Information

Patent Number: US20120259267A1
Application Number: US13496486A
Inventor: Almutairi, Adah | Fomina, Nadezda | Sankaranarayanan, Jagadis
Priority Date: 23 Sep 2009
Priority Number: US20120259267A1
Application Date: 28 Jun 2012
Publication Date: 11 Oct 2012
IPC Current: C07C0049175 | A61K0039395 | A61K005100 | A61M003700 | B01J001908 | C07D031102 | C08F002056
US Class: 604020 | 2504921 | 42400111 | 4241301 | 525284 | 549283 | 568414
Assignee Applicant: The Regents of the University of California
Title: Chemically Amplified Response Strategies for Medical Sciences
Usefulness: Chemically Amplified Response Strategies for Medical Sciences
Summary: For delivering Payload to tissue, where the Payload comprises pharmaceutical agent, stem cell differentiation agents, immunogens, and antibodies (claimed); for amplifying sensitivity to electromagnetic radiation, or light, such as UV light or near infrared light.
Novelty: Composition for delivering Payload such as pharmaceutical agent, stem cell differentiation agents, immunogens and antibodies, to tissue comprises multi-photon responsive element covalently linked to self-immolative backbone subunit