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Fast Correction of Inhomogeneous Magnetic Field Distortion in MRI

Technology Benefits: Highly anatomically accurateFastPortable

Technology Application: Brain tumor assessmentWhite matter tractographyFunctional response of the brain (fMRI)

Detailed Technology Description: The subject invention gives a method by which to process MRI data in Echo Planar Imaging (EPI) systems to compensate for the high level of distortion that is typical in EPI, both from gradient variations in the MRI system, as well as induced MRI fields within the patient. The corrective method given here can be applied in under one minute to the typical scan, improving the use of EPI in the clinical setting. EPI is a common acquisition modality where high temporal resolution is required, such as in fMRI which is used to track hemodynamic response to neuronal activity in the brain, or in Diffusion Weighted Imaging (DWI) where EPI is used for early detection of stroke. EPI is a data acquisition strategy used in MR imaging, permitting very rapid data acquisition. The method was originally described by Mansfield in 1977 and employs the following imaging strategy. Rather than acquiring a single image line (in k space) after the preparation phase of the pulse sequence, the entire MR image is acquired. Multiple variations of this image acquisition strategy have been devised since its inception, but the basic concept is that multiple rather than single image lines are acquired after spin preparation.

Supplementary Information: Patent Number: US8160319B2
Application Number: US2008152842A
Inventor: Holland, Dominic | Dale, Anders
Priority Date: 18 May 2007
Priority Number: US8160319B2
Application Date: 16 May 2008
Publication Date: 17 Apr 2012
IPC Current: G06K000900
US Class: 382128 | 600410
Assignee Applicant: The Regents of the University of California
Title: Reducing distortion in magnetic resonance images
Usefulness: Reducing distortion in magnetic resonance images
Summary: Machine-implemented method for reducing image distortion in MRI that is utilized in a medical field and biological field.
Novelty: Machine-implemented image distortion reducing method for e.g. medical field, involves reducing distortion in MRI image using estimated displacements, and producing MRI image that has reduced distortion

Industry: Biomedical

Sub Category: Medical Imaging

Application No.: 8160319

Others

State Of Development

Working C++ code is developed for performing image correction and software may be particularly useful to MRI manufacturers. The work is described in the first reference under "Related Materials."

Other Information

Issued US Patent No. 8,160,319 available for non-exclusive licensure

Related Material

Holland D, et al., Efficient correction of inhomogeneous static magnetic field-induced distortion in Echo Planar Imaging. Neuroimage. 2010 50(1):175-83.
White NS, et al.,.,Improved conspicuity and delineation of high-grade primary and metastatic brain tumors using "restriction spectrum imaging": quantitative comparison with high B-value DWI and ADC. AJNR Am J Neuroradiol. 2013 34(5) 958-64, S1.

McDonald CR, et al., Changes in fiber tract integrity and visual fields after anterior temporal lobectomy. Neurology. 2010 75(18) 1631-8.
Vardal J, et al., Correction of B0-distortions in echo-planar-imaging-based perfusion-weighted MRI. J Magn Reson Imaging. 2014 39(3) 722-8. http://www.ncbi.nlm.nih.gov/pubmed/24123663
Brown TT, et al., Neuroanatomical assessment of biological maturity. Curr Biol. 2012 22(18) 1693-8
A. M. Dale Laboratory

Background

Magnetic Resonance imaging (“MRI”) used to map white matter tractography, as well as perfusion/diffusion-related techniques for tumor assessment (DTI/DWI) and functional brain studies (fMRI) all rely on Echo Planar Imaging (EPI). However, EPI is subject to severe geometric and intensity distortion. Quantitative anatomical precision in such measurements requires that the images are accurately corrected.

Additional Technologies by these Inventors

A Restriction Spectrum Imaging Method and Device for Probing Tissue Microstructure

Tech ID/UC Case

19806/2007-217-0

Related Cases

2007-217-0

*Abstract: None

*IP Issue Date: Apr 17, 2012

*Principal Investigator: Name: Anders Dale
Department:

Name: Dominic Holland
Department:

Country/Region: USA

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