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Non-Invasive Mapping of Perfusion Territories Using MRI

Technology Application

• Diagnostic imaging in stroke, carotid occlusion, and cerebral ischemia • Image based guidance for intra-arterial treatment of stroke • Risk assessment for stroke • Evaluation of blood supply to tumors • Evaluation of blood supply to organ transplants such as kidneys • Evaluation of collateral blood supply in carotid or other cerebrovascular disease

Detailed Technology Description

MR perfusion imaging based on arterial spin labeling (ASL) uses arterial blood water as the endogenous contrast agent, making possible for this non-invasive procedure to be widely available at relatively low cost. To date, most perfusion studies carried out by MRI have obtained perfusion maps that include contributions from all the arteries feeding the brain. In perfusion territory imaging, blood in individual or groups of feeding arteries are tagged separately and the images acquired map the vascular distribution of those feeding arteries. A researcher at UC San Diego has developed a non-invasive mapping approach of perfusion territories using MRI. It allows one to place a person in an MRI scanner, without the use of any exogenous agents, and map the tissue regions that are supplied with blood from different feeding arteries in a time-efficient manner practical for clinical applications. Compared to the pulsed methods developed for this use by others, the UC San Diego’s pseudo-continuous tagging approach is superior in four ways: • Higher SNR • Better vessel selectivity • Flexibility in tagging geometry • Potential for separation of vascular territories above the Circle of Willis in the brain The relative tagging efficiency for each vessel is measured directly from the ASL data and is used in the decoding process to improve the separation of vascular territories. High SNR maps of left carotid, right carotid, and basilar territories are generated in six minutes of scan time. Software has been developed on a GE MRI scanner and can be adapted to other MRI scanners.

Supplementary Information

Patent Number: US8195274B2
Application Number: US2008111133A
Inventor: Wong, Eric C.
Priority Date: 27 Apr 2007
Priority Number: US8195274B2
Application Date: 28 Apr 2008
Publication Date: 5 Jun 2012
IPC Current: A61B000505 | G01V000300
US Class: 600419 | 324306 | 324307 | 324309 | 600410
Assignee Applicant: The Regents of the University of California
Title: Mapping of vascular perfusion territories
Usefulness: Mapping of vascular perfusion territories
Summary: Method for mapping vascular perfusion territory in a human brain using an MRI system (claimed) that is utilized in medical and biological fields.
Novelty: Vascular perfusion territory mapping method for human brain, involves measuring tagging efficiency for blood vessels and separating vascular perfusion territories by using measured tagging efficiency in decoding process

Industry

Disease Diagnostic/Treatment

Sub Category

Other Disease

Application No.

8195274

Others

Related Materials

Patent application titled “Mapping of Vascular Perfusion Territories”

Tech ID/UC Case

19805/2007-238-0

Related Cases

2007-238-0

*Abstract

None

*IP Issue Date

Jun 5, 2012

*Principal Investigator

Name: Eric Wong

Department:

Country/Region

USA