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Method for Manipulating and Heating of Discrete Droplets Using Magnetic Particles Derived from Porous Silicon

Technology Benefits

Efficient heat transfer from the magnetic layer to the droplet Multi-layer porous magnetic particle adhere to the surface of a drop Externally applied electromagnetic stimulus heats the particles with the associated droplet Heating of droplets that can be identified by a unique spectral code Discrete microliter-scale liquid droplets Ability of the porous Si host to localize high concentration of magnetite nanoparticles allows heating at relatively low fields Level of heating related to the number of microparticles introduced into a host droplet, and their degree of magnetization Group of discrete droplets can be simultaneously heated to different temperatures using a single coil

Technology Application

Tagging, manipulating and heating small volumes of liquids. The small size of the particles facilitates ready incorporation into various hosts, e.g. test kits, assays, powders, liquids, glass, paper, and in vivo detection is enabled by the biocompatible silicon particles. The technology has a variety of applications, including: In vivo drug delivery and labeling Biological screening and labeling High-throughput screening of molecules for genomics and proteomics Drug discovery Chemical labeling Optical signaling and displays Product marking Security identification

Detailed Technology Description

This technology is a method for precise local heating of small liquid volumes using magnetic porous Si microparticles. Dr. Sailor and his collaborators at UCSD have previously demonstrated that porous silicon photonic crystals can be engineered to have amphiphilic properties. Adding magnetite to the particles endows them with the ability to be manipulated with magnetic fields, providing a means to direct the motion of liquid droplets in microfluidics applications. By application of an alternating magnetic field the properties of the porous Si particles are utilized for manipulating and heating the droplet. The particle includes a hydrophilic host layer with magnetic nanoparticles and a hydrophobic encoding layer that define a spectral code. The droplets can be therefore identified using a light spectrum reflected from the encoding layer. In addition, the particle structure allows an efficient heat transfer from the magnetic layer to the droplet.

Supplementary Information

Patent Number: US8377147B2
Application Number: US2008300369A
Inventor: Sailor, Michael J. | Park, Ji-Ho | Derfus, Austin | Segal, Ester | Vecchio, Kenneth S. | Bhatia, Sangeeta N.
Priority Date: 19 Jul 2004
Priority Number: US8377147B2
Application Date: 23 Mar 2009
Publication Date: 19 Feb 2013
IPC Current: B32B001500 | B44C000122
US Class: 216002 | 977962 | 216022 | 216024 | 216039 | 216056 | 428357 | 428402 | 428403 | 4286921 | 4350061 | 4351731 | 4352871 | 977838 | 977960 | 4351721
Assignee Applicant: The Regents of the University of California
Title: Control of materials and porous magnetic particles
Usefulness: Control of materials and porous magnetic particles
Summary: Control of associated material is used for forming magnetic porous particles (claimed) used in optoelectronics, encoding, security, life science, product marking, food processing, agriculture and chemical and biological testing. Can also be used for controlled manipulation and heating of solid or liquid micro or nano particles, delivery, targeting and controlled release of therapeutic and/or diagnostic reagents in patients, high throughput screening of molecules for genomics, proteomics and drug delivery applications, and controlled manipulation and heating of liquids containing cells, proteins and biological systems.
Novelty: Control of associated material used for forming magnetic porous particles, involves associating associated material with microparticles having magnetic material within its pores, and controlling microparticles with magnetic field

Industry

Chemical/Material

Sub Category

Chemical/Material Application

Application No.

8377147

Others

State Of Development

This technology is offered exclusively or nonexclusively in the US and/or worldwide territories. A commercial sponsor for potential future research is sought.

UCSD Researcher

Michael J. Sailor, Ph.D., is Professor in the Department of Chemistry and Biochemistry at UCSD.

Related Materials

Sailor Research Group
Michael J. Sailor

Tech ID/UC Case

19787/2006-176-0

Related Cases

2006-176-0

*Abstract

The control of materials in microscale quantities is of interest in a wide range of fields. A particular area of microscale material control that has drawn much attention is microfluidics. Heating techniques developed for use in microfluidic networks are problematic due to the requirement for efficiency in the localized heating of the individual droplets with minimal heat transfer to the surrounding area.

*IP Issue Date

Feb 19, 2013

*Principal Investigator

Name: Sangeeta Bhatia

Department:

Name: Austin Derfus

Department:

Name: Ji-Ho Park

Department:

Name: Michael Sailor

Department:

Name: Ester Segal

Department:

Name: Kenneth Vecchio

Department:

Country/Region

USA