pH-"Tunable" Nano-Particle Drug Delivery System
These features should prove extremely relevant for clinical applications, from cancer to ophthalmology, where increased efficacy and reduce drug toxicity can enhance the therapeutic profile and/or extend patient life for promising and useful drugs.
A new class of linkers has been developed to address these limitations. These linkers: Undergo controlled hydrolysis at physiological temperature and in mild aqueous, acidic environments.Can be tuned to hydrolyze with half-lives from thirty minutes to greater than nine months. Accommodate a wide range of biocompatible drug carriers. Flexibly conjugate to a wide variety of drugs (via alcohol, amine, or imidazole).
Patent Number: US8575359B2
Application Number: US2008295858A
Inventor: Yang, Jerry | Kong, Seong Deok | Luong, Alice | Howell, Stephen
Priority Date: 4 Apr 2006
Priority Number: US8575359B2
Application Date: 20 Sep 2010
Publication Date: 5 Nov 2013
IPC Current: C07D023300 | C07D023302 | C07D023354 | C07D023360 | C07H001524
US Class: 5483001 | 5360064 | 5483415
Assignee Applicant: The Regents of the University of California
Title: Acid-sensitive linkers for drug delivery
Usefulness: Acid-sensitive linkers for drug delivery
Summary: As acid-sensitive linkers for delivering drugs useful for treating cancer and for inhibiting cell proliferation and growth of cancer cells.
Novelty: New imidazole derivatives, as acid-sensitive linkers for delivering drugs useful for treating cancer and for inhibiting cell proliferation and growth of cancer cells
Disease Diagnostic/Treatment
Cancer/Tumor
8575359
Intellectual Property Info See issued patent, below. Related Materials Additional Technologies by these Inventors Tech ID/UC Case 19435/2006-140-0 Related Cases 2006-140-0
USA
