Media.Player

Compositions and Methods for Activating Toll-Like Receptors

Detailed Technology Description

The present invention relates to compositions of a member of the cholesterol-dependent cytolysin (CDC) family and methods of using these compositions to activate toll-like receptor 4 and to identify modulators of toll-like receptor 4 activation. Activation of toll-like receptor 4 by endotoxin or lipopolysaccharide (LPS) can lead to septic shock or septicemia. Compounds identified as modulators, and more particularly inhibitors, of toll-like receptor 4 activation by a member of the CDC family are expected to be useful in the treatment of septic shock and/or septicemia. It is believed that isolated CDCs, fragments, or mimetics may inhibit the interaction of toll-like receptor 4 and endotoxin or LPS.

Supplementary Information

Patent Number: US7521073B2
Application Number: US2007764469A
Inventor: Rest, Richard | Karin, Michael | Park, Jin Mo
Priority Date: 12 Oct 2004
Priority Number: US7521073B2
Application Date: 18 Jun 2007
Publication Date: 21 Apr 2009
IPC Current: A61K003500 | A61P003100 | C12N000500
US Class: 424780 | 4350078 | 435170 | 435375
Assignee Applicant: Philadelphia Health and Education Corporation,Philadelphia,PA
Title: Compositions and methods for activating Toll-like receptor 4
Usefulness: Compositions and methods for activating Toll-like receptor 4
Summary: For treating septicemia or septic shock in subject; activating Toll-like receptor 4 (TLR4); inhibiting binding and/or interaction of TLR4 with endotoxin; and identifying modulator of TLR4 activation (claimed).
Novelty: Composition useful for treatment of septicemia or septic shock comprises an agent that inhibits activation of Toll-like receptor 4 by cholesterol-dependent cytolysin

Industry

Biomedical

Sub Category

Medical Composition

Application No.

7521073

Others

State Of Development

A patent has issued for this invention, see 20070248706.

Related Materials

Park JM, Ng VH, Maeda S, Rest RF, Karin M. (2004) Anthrolysin O and Other Gram-Positive Cytolysins Are Toll-Like Receptor 4 Agonists. J Exp Med; 200(12):1647-55.

Tech ID/UC Case

19207/2009-057-0

Related Cases

2009-057-0

*Abstract

None

*IP Issue Date

Apr 21, 2009

*Principal Investigator

Name: Michael Karin

Department:

Name: Jin Mo Park

Department:

Name: Richard Rest

Department:

Country/Region

USA