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A Method To Measure Neurotransmitters In Vivo

Technology Application

The superior specificity and temporal resolution of the invention over existing methods allows its use in basic science research and in neurotoxicological studies. This invention can also be applied to assess the effects of novel neurological or neuropsychiatric drugs during pre-clinical, live animal studies. In particular, the demonstrated ability of the method to detect release of cortical acetylcholine is especially suitable to validate cholinergic therapies in animal models of Alzheimer's disease and to develop cognitive enhancers.

Detailed Technology Description

Scientists at the UC San Diego have developed a method to detect neuroactive substances in the live brain. This technique is designed to measure in vivo levels of biochemical compounds (e.g., neurotransmitters or neuromodulators) with high specificity, sensitivity, and temporal resolution. The invention relies on a cell-based bioassay consisting of sensors called sentinel cells that report the presence of a specific neurotransmitter by changing their fluorescence. Sentinel cells are implanted inside the brain and their optical signal is detected in vivo with two-photon laser scanning microscopy (TPLSM). The modularity of this technique allows for the realization of different receptor/sensor pairs as a means to detect many kinds of neurochemicals, including neuropeptides.

Supplementary Information

Patent Number: US6963604B2
Application Number: US2004814448A
Inventor: Erdogmus, Deniz | Lazaro, Marcelino | Principe, Jose Carlos | Santamaria, Ignacio
Priority Date: 31 Mar 2003
Priority Number: US6963604B2
Application Date: 31 Mar 2004
Publication Date: 8 Nov 2005
IPC Current: H04L002503
US Class: 375232 | 375229 | 375230 | 708322 | 708323
Assignee Applicant: University of Florida Research Foundation Inc.inesville
Title: Blind equalizers using probability density matching and parzen windowing
Usefulness: Blind equalizers using probability density matching and parzen windowing
Summary: In digital communication system.
Novelty: Iterative method in digital communication system, involves using kernel density estimate where different values of kernel size indicates blind or decision-directed equalization mode, processing input signal using blind equalization mode

Industry

Biomedical

Sub Group

DNA/Gene Engineering

Application No.

8663604

Others

Other Information

A patent application has been filed.

Tech ID/UC Case

19176/2007-283-0

Related Cases

2007-283-0

Country/Region

USA

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