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Method For Preparation Of Micellar Hybrid Nanoparticles For Combined Therapeutic And Diagnostic Medical Applications

Technology Benefits

In-vivo stability allows for prolonged integrity in systemic circulation. Micellar structure allows delivery of a broad array of payloads, including, magnetic particles, quantum dots, or a therapeutic agent. Reduced cytotoxicity of both hydrophobic drugs and nanoparticle itself. Enables co-delivery of therapeutic agents and diagnostic agents that enable imaging.

Technology Application

Medical imaging Cancer diagnostics and therapeutics Diagnostic and therapeutics for various diseases Vaccines

Detailed Technology Description

This invention provides both the composition and a novel method for creating micellar hybrid nanoparticles that exhibit substantial in vivo circulation times, allowing them to contain a diverse payload for periods of time sufficient for delivery and subsequent release to a desired tissue. In addition, this technology readily facilitates the simultaneous targeted delivery of both therapeutic and imaging agents to diseased tissue in vitro or in vivo.

Supplementary Information

Patent Number: US20120059240A1
Application Number: US13219906A
Inventor: Sailor, Michael J. | Bhatia, Sangeeta N. | Park, Ji-Ho | Von Maltzahn, Geoffrey A.
Priority Date: 24 Jun 2008
Priority Number: US20120059240A1
Application Date: 29 Aug 2011
Publication Date: 8 Mar 2012
IPC Current: A61B0005055 | A61K000914 | A61K0031704 | A61K004900 | A61K004918 | A61N000210 | A61P003500 | C12Q000102 | C12Q000168 | G01N0033566 | B82Y000500 | B82Y002500 | B82Y004000
US Class: 600409 | 4240091 | 4240093 | 424490 | 4350061 | 4350071 | 435029 | 514034 | 600012 | 977773 | 977774 | 977838 | 977915
Assignee Applicant: Massachusetts Institute of Technologymbridge | The Regents of the University of California
Title: METHOD FOR PREPARATION OF MICELLAR HYBRID NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS AND COMPOSITIONS THEREOF
Usefulness: METHOD FOR PREPARATION OF MICELLAR HYBRID NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS AND COMPOSITIONS THEREOF
Summary: The compositions are useful for treating or diagnosing disease or disorder in subject (claimed). Disease or disorder includes cancer, neoplasm and proliferative disorders.
Novelty: New micelle compositions encapsulating different nanostructures at least two of nanostructures having different excitation/emission spectrums or detectable signals, useful for treating or diagnosing disease, e.g. cancer, in subject

Industry

Disease Diagnostic/Treatment

Sub Category

Cancer/Tumor

Others

State Of Development

This technology is offered exclusively or nonexclusively for U.S. and/or worldwide territories. A commercial sponsor for potential future research is sought.

This technology has been used in vitro and in vivo to deliver an anti-cancer agent and two types of nanoparticles that aid in fluorescence and magnetic resonance imaging to diseased tissue (see reference below).

Related Materials

Park JH, von Maltzahn G, Ruoslahti E, Bhatia SN, Sailor MJ (2008). Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery. Angew Chem Int Ed Engl. 47(38):7284-8.

Tech ID/UC Case

19171/2008-313-0

Related Cases

2008-313-0

*Abstract

Multifunctional nanoparticles have the potential to deliver both therapeutics and diagnostics to tissues simultaneously using a single nanodevice. To date, several types of hybrid nanosystems have been developed and used in vitro for magnetic cell separation and targeting. However, the in vivo utility of these nanocomposites may be limited due to poor stability or short systemic circulation times. Furthermore, existing technologies do not adequately allow for co-delivery of a therapeutic and an agent enabling advanced diagnostic imaging.

*Principal Investigator

Name: Sangeeta Bhatia

Department:

Name: Ji-Ho Park

Department:

Name: Michael Sailor

Department:

Name: Geoffrey von Maltzahn

Department:

Country/Region

USA