Antibodies targeting mammalian Sterol Regulatory Element Binding Proteins (SREBP) 1 and 2
- Technology Benefits
- § The developed antibodies have high affinity and specificity for SREBP 1 and 2, relative to commercially available reagents § High utility as a research tool to identify transcriptional targets § Potential robust immunotherapeutic
- Detailed Technology Description
- SREBP 1 and 2 are important regulators of fatty acid and cholesterol metabolism, respectively. While these proteins are known to play a significant role in lipid homeostasis, there is still much to be learned about their physiological targets, both related to lipid biosynthesis and other pathways. Recently, UCI researchers identified 426 targets of just SREBP-1. These researchers have prepared antibodies to fragments of SREBP 1 and 2 that have greater affinity and specificity than current commercially available reagents. These novel antibodies are highly desirable tools for studying SREBP in culture and animal models. Furthermore, SREBP antibodies may also be promising immunotherapeutics in metabolic diseases.
- Others
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State Of Development
In vivo studies in mouse model
Related Materials
Tech ID/UC Case
27241/2015-862-0
Related Cases
2015-862-0
- *Abstract
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Sterol Regulatory Element Binding Proteins (SREBP) are important factors that control lipid homeostasis in mammals. Researchers at UCI have prepared antibodies that have good affinity and specificity for human SREBP1/2 for use as research tools. These antibodies have application in genetic and immunotherapeutic research areas.
- *Principal Investigator
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Name: Timothy Osborne
Department:
- Country/Region
- USA
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