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Monoclonal Antibodies Against Spc24/25 (Clone 2A10)

Technology Benefits: Specific antibody to detect SPC24 and SPC25 by antibody-antigen complex formation.

Technology Application: Immunocytochemistry/immunofluorescence Immunoprecipitation Western blot

Detailed Technology Description: SPC24 and SPC25 act as components of the essential kinetochore-associated NDC80 complex. This complex is required for chromosome segregation and spindle checkpoint activity. SPC24 and SPC25 are required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The described mouse antibody binds to human SPC24 and SPC25 and has been described for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

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Additional Technologies by these Inventors

Tech ID/UC Case

25542/2011-378-0

Related Cases

2011-378-0

*Abstract: Mouse hybridoma cell line secret antibody against the human Kinetochore protein Spc24 (SPC24) and Kinetochore protein Spc25 (SPC25). This antibody has been tested for use in immunocytochemistry/immunofluorescence, immunoprecipitation, and western blot.

*Principal Investigator: Name: Wen Hwa Lee
Department:

Name: Randy Wei
Department:

Country/Region: USA

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