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Novel Methods to Prevent and Treat Liver and Colon Cancer

Technology Benefits: Target gut microbiota and gut-liver axis Reversing the pathways that are abnormally occurred in both colon and liver cancer Early diagnosis Prevent by reducing inflammation and boost metabolism Cancer treatment

Technology Application: Prevention and treatment of colon and liver cancer

Detailed Technology Description: The incidence of liver and colon cancer is rising due to obesity and metabolic syndrome. It has been found that the gut microenvironment is altered due to unhealthy diet in animals with dysbiosis, lack of nutrients, and dysregulated bile acid synthesis. Despite this correlation, most treatments for liver and colon cancer (such as a colectomy or chemotherapy) do not attempt to address the alteration of the gut microenvironment as a form of recovery. Researchers at the University of California, Davis have developed a method to treat colon and liver cancer by using retinoids and histone deacetylase inhibitors (HDAC inhibitors) using both natural compounds and synthetic chemicals. In addition, the researchers have uncovered novel mechanism for such anti-cancer effects. Retinoids and HDAC inhibitors can work through specific microRNAs (which are tumor suppressive) to induce apoptosis and arrest of liver and colon cancer cells. Additionally, they reduce inflammation and improve metabolism. The treatment has been successfully tested in vitro in human colon and liver cancer cells, ex vivo in human colon and liver biopsies and in vivo in specific knockout mice as well as xenograt tumor models.

Others: Related Materials
Fan Yang, Ying Hu, Hui-Xin Liu, and Yu-Jui Yvonne Wan MiR-22-silenced Cyclin A Expression in Colon and Liver Cancer Cells Is Regulated by Bile Acid Receptor J. Biol. Chem. 2015 290: 6507-. doi:10.1074/jbc.M114.620369

Tech ID/UC Case
27056/2016-363-0

Related Cases
2016-363-0

*Abstract: Researchers at the University of California, Davis have developed a method to treat liver and colon cancer using natural or synthetic retinoids in combination with histone deacetylase inhibitors.

*IP Issue Date: May 17, 2018

*Principal Investigator: Name: Yu-Jui Yvonne Wan
Department:

Country/Region: USA

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