Coordinative Alignment Of Molecules In Chiral Metal Organic Frameworks
Advantages of this strategy include: (i) the molecules make covalent bonds to well-defined metal sites of the MOF; these bonds anchor them and lower their motional degrees of freedom, thereby promoting their alignment into an ordered pattern across the interior of the crystalline framework; and (ii) the absolute structure of the chiral MOF framework serves as a reference for the direct determination of the absolute configuration of bound chiral molecules. Indeed, this latter feature forgoes the reported pseudo-symmetry problems that have obscured the absolute structures that specify the enantiomorph in achiral host framework systems.
The invention can be used to determine the precise crystal structure of pharmaceutical molecules, natural products, and protein structures by diffraction techniques, such as, x-ray, neutron, and electron diffractions.
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Additional Technologies by these Inventors Tech ID/UC Case 26003/2017-006-0 Related Cases 2017-006-0
USA
