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Methods and Materials to Treat Lymphangiogenesis

Technology Benefits

Local or systemic administrationDemonstrated in mouse modelDemonstrated in human in vitro culture system

Technology Application

Corneal vascularization in various diseasesCorneal transplants in low-risk and high-risk settingsOther tissue or organ transplantOther immune- or lymphatic-related disorders, such as cancer metastasis

Detailed Technology Description

None

Others

Related Materials

"MicroRNA-184 Regulates Corneal Lymphangiogenesis" by Grimaldo S, Yuen D, Theis J, Ng M, Ecoiffier T, Chen L.

Additional Technologies by these Inventors

• Live Imaging of Corneal Lymphatic Vessels
• Modulation of Ang-2 to Treat Pathologic Lymphangiogenesis
• Combined Blockade of VEGFR-3 and VLA-1 to Improve Transplant Survival
• Modulation Of Lymphatic Valve And Vessel Formation To Treat Diseases, Such As Trasplant Rejection

Tech ID/UC Case

25508/2016-060-0

Related Cases

2016-060-0

*Abstract

The lymphatic vascular network penetrates most tissues in the body and plays important roles in a broad spectrum of functions, including immune surveillance, fat absorption and interstitial fluid homeostasis. Numerous disorders have been found to be associated with lymphatic dysfunction, such as cancer metastasis, inflammatory and immune diseases, infection, transplant rejection, obesity, hypertension and lymphedema. However, to date, there is still little effective treatment for most lymphatic disorders. Researchers at UC Berkeley (UCB) are working to advance the understanding of the mechanisms underlying pathologic lymphatic processes, such as lymphangiogenesis (LG), for new preventive measures and treatments. MicroRNAs are a class of small noncoding RNAs that negatively regulate gene expression by binding to complimentary sequences of target messenger RNA. UCB researchers are specifically investigating the role of microRNA 184 (miR-184) in corneal LG in vivo and dermal lymphatic endothelial cells (LECs) in vitro. Using preclinical animal models combined with human cell cultures, the researchers have discovered that miR-184 which is naturally expressed in the cornea is critically involved in LG and could potentially be used as an inhibitor of LG. Further research and understanding of these data may produce targets for miR-184 for new approaches to prevent or treat lymphatic disease which occurs both inside and outside the eye.

*Applications

• Corneal vascularization in various diseases
• Corneal transplants in low-risk and high-risk settings
• Other tissue or organ transplant
• Other immune- or lymphatic-related disorders, such as cancer metastasis

*Principal Investigator

Name: Lu Chen

Department:

Name: Sammy Grimaldo

Department:

Country/Region

USA