Zippering Antibody Transducer Nanomachine
- Technology Benefits
- highly miniaturized both signaling and treatment capabilities no external power source real-time biomolecular signal amplification
- Technology Application
- targeted drug delivery biomolecular concentration dependent release of signaling molecules,drugs, or imaging agents biomarker detection in vivo and in vitro clinical diagnostics
- Detailed Technology Description
- None
- Others
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Additional Technologies by these Inventors
- Wireless High-Density Micro-Electrocorticographic Device
- Methods and Apparatus to Monitor Fracture Healing
Tech ID/UC Case
19886/2010-038-0
Related Cases
2010-038-0
- *Abstract
-
Targeted drug delivery is often critical in clinical treatments. Ideally, such delivery would be automatically responsive to physiologic parameters. ALZA, Durect, and other companies have made considerable investments toprovide such responsive dosing. More recently, monoclonal antibodies tagged with radioactive cancer treatment moieties have been developed to provide more focused treatment of cancers, sparing normal cells from these potent toxins. Implantable insulin pumps have been developed to provide a more natural philological level of insulin to diabetics.
This new nanomachine provides biomolecularconcentration dependent release of signaling molecules, drugs, or imaging agents. This new nanomachine, which uses the binding forces of an analyte to bend a component in a nano-device, will detect with great specificity anyantigenic bimolecular and transduce that signal into the release ofsecondary species. The secondary species need not be antigenic and couldinclude proteins, small molecules, haptens, imaging agents, nanoparticles,polymers, etc. The antigenic nature of the detection makes the devicebroadly applicable. The device is capable of operation in physiologicsolutions and requires no external power source. This fundamentalarchitecture exerts mechanical forces on a coupled delivery vehicle that contains a secondary species when the presence of a biomolecular species is detected.
- *Principal Investigator
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Name: Gabriel Lavella
Department:
Name: Michel Martin Maharbiz
Department:
Name: Roberto Morfino
Department:
- Country/Region
- USA
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