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Biocompatible Nanostructures For Ultrasensitive Biomolecular Sensors And Cellular Imaging

Technology Benefits: Near IR excitation, Batch nanofabrication, Extremely strong field emitting effect, Biocompatible

Technology Application: Ultrasensitive Label-Free Biodefence Detector, Ultrasensitive SERS system, Molecular Imaging Tool, Drug Delivery

Detailed Technology Description: None

Supplementary Information: Patent Number: US8685659B2
Application Number: US2007814939A
Inventor: Zetter, Bruce R. | Feldman, Adam S. | McDougal, W. Scott
Priority Date: 28 Jan 2005
Priority Number: US8685659B2
Application Date: 3 Jun 2009
Publication Date: 1 Apr 2014
IPC Current: G01N0033574
US Class: 43500723
Assignee Applicant: Children's Medical Center Corporation,Boston | The General Hospital Corporation,Boston
Title: Method for diagnosis and prognosis of epithelial cancers
Usefulness: Method for diagnosis and prognosis of epithelial cancers
Summary: For diagnosing a cancer of epithelial origin, such as bladder cancer (e.g. invasive bladder cancer), liver cancer, breast cancer, skin cancer and lung cancer, in a patient (claimed).
Novelty: Diagnosing cancer of epithelial origin such as bladder cancer, comprises detecting presence of epithelial cancer biomarker, e.g. profilin, in biological sample such as urine

Industry: Biomedical

Sub Category: Medical Imaging

Application No.: 8149397

Others: Tech ID/UC Case
17468/2005-032-0

Related Cases
2005-032-0

*Abstract: A variety of nanostructures have been developed for use in biomolecular detection. The nanosphere is the most widely used structure because of unique, highly desirable properties that make it a superior detection platform for life science research, in vitro diagnostic testing, and in vivo imaging. Other structures such as nanotips, nanorings, and nanocups have also been demonstrated for use in high resolution SERS spectroscopy and imaging. These structures provide significant field enhancement in experiments and in simulations but they have proved to be difficult to fabricate consistently.

Researchers at the University of California, Berkeley have developed a new nanostructure that is biocompatible and incorporates the advantages of nanotips, nanospheres, and nanorings. Unlike present nanosphere-based SERS spectroscopy and imaging, which uses a wavelength of 500-600 nm, the new structure can be excited at near the infrared range. Excitation at longer wavelengths provides deeper penetration into tissue with minimal photothermal damage, and excitation of the nanostructure does not cause fluorescence of other biomolecules.

The structure developed at Berkeley has a much stronger field emitting or "antenna" effect than previously seen even from nanotips and nanorings. The excited "hotspot" of the structure has been demonstrated to have an enhancement factor larger than 10^10. Batch fabrication is straightforward and does not require e-beam lithography. These characteristics make the improved nanostructure ideal for application in molecular medicine and in ultrasensitive Raman, biomolecular, and cellular imaging.

http://biopoems.berkeley.edu

*IP Issue Date: Apr 3, 2012

*Principal Investigator: Name: Jaeyoun Kim
Department:

Name: Luke Lee
Department:

Name: Yu Lu
Department:

Name: Gang Liu
Department:

Country/Region: USA

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