Murine H60 Gene (plasmid) For Minor Histocompatibility Antigen
- Detailed Technology Description
- None
- Others
-
Tech ID/UC Case
17138/2002-044-0
Related Cases
2002-044-0
- *Abstract
-
Minor histocompatibility (H) antigens elicit T cell responses and thereby cause chronic graft rejection and graft-vs.-host disease among MHC identical individuals. Although numerous independent H loci exist in mice of a given MHC haplotype, certain H antigens dominate the immune response and are thus of considerable conceptual and therapeutic importance. The H60 gene was isolated as a cDNA clone from the mouse strain BALB.B. This gene contains an antigenic peptide that elicits a strong cytotoxic T cell response when C57BL/6 mice are immunized with BALB.B spleen cells.
References:
Malarkannan et al. 1998. J Immunol. 161:3501-9.
Karttunen et al. 1992. PNAS 89:6020-4.
- *Principal Investigator
-
Name: Nilabh Shastri
Department:
- Country/Region
- USA
