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Focused Droplet Nebulizer for Evaporative Light Scattering Detector

IP Title

FOCUSED DROPLET NEBULIZER FOR EVAPORATIVE LIGHT SCATTERING DETECTOR

Detailed Technology Description

None

Supplementary Information

Patent Number: US7760355B2
Application Number: US2005191272A
Inventor: Larsen, David W. | Xu, Zhi
Priority Date: 27 Jul 2005
Priority Number: US7760355B2
Application Date: 27 Jul 2005
Publication Date: 20 Jul 2010
IPC Current: G01N001502
US Class: 356335 | 356438
Assignee Applicant: The Curators of the University of Missourilumbia
Title: Focused droplet nebulizer for evaporative light scattering detector
Usefulness: Focused droplet nebulizer for evaporative light scattering detector
Summary: Used in evaporative light scattering detector (ELSD) (claimed) that is utilized for liquid Chromatography (LC) analysis of wide variety of samples.
Novelty: Focused droplet nebulizer for use in evaporative light scattering detector, has piezo membrane micro pump, and tiny outlet orifice that is sized to expel droplet upon contraction of piezo membrane

Industry

Measurement/Testing

Sub Category

Measurement Platform

Application Date

Jul 27, 2005

Application No.

7,760,355

Others

*Abstract

REF: 05UMS068FIELD OF THE INVENTION The invention is in the field of evaporative light scattering detection. BACKGROUND Evaporative light scattering detectors (ELSDs) are used routinely for Liquid Chromatography (LC) analysis and can be used for analyzing a wide variety of samples. In an ELSD, a liquid sample is converted to droplets by a nebulizer. Current nebulizers, however, limit the effectiveness of detection capabilities of ELSDs. Researchers at UM-St. Louis have developed a FOCUSED DROPLET NEBULIZER FOR EVAPORATIVE LIGHT SCATTERING DETECTOR to overcome the problems inherent with traditional nebulizers. INVENTIONThe invention produces substantially uniform droplets of a predetermined size, which are pushed out through a small outlet orifice by the contraction of a chamber. The droplets can be carried on a substantially non-divergent path in a drift tube. A piezo membrane micro pump acts in response to an electrical control signal to force a droplet out of the outlet orifice. The nebulizer can operate at frequencies permitting a stream of individual droplets of the predetermined size to be sent along the substantially non-divergent path in the drift tube in an ELSD device. BENEFITS- Substantial noise reduction because large droplets are eliminated.- Increased signal because all droplets are of the right size to contribute to the signal.- Decreased carrier gas requirement.- Smaller than the standard nebulizer.- Possible to decrease the internal size of the drift tube.- Possible to operate the drift tube at lower temperatures than at present, which will minimize signal loss for analytes that tend to partially vaporize.IP STATUSUS Patent 7,760,355CONTACTTamara WilgersDirector, Technology Commercialization & Economic Development University of Missouri-St. Louiswilgerst@umsl.edu314-516-6884

*IP Issue Date

Jul 20, 2010

*IP Publication Date

Feb 1, 2007

*Principal Investigator

Name: David Larsen

Department:

Name: Zhi Xu

Department:

Country/Region

USA