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RIBONUCLEOPROTEIN IMMUNOPRECIPATION-MICROARRAY FOR IDENTIFYING CANCER GENES

Detailed Technology Description

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*Abstract

University of MissouriOffice of Technology Management & Industry RelationsNon-Confidential Abstract of InventionUM Disclosure No. 09UMC071RIP-CHIP PROFILING OF BREAST CANCER SUBTYPESThe correlation between steady state mRNA levels and protein products is known to be poor. Posttranscriptional gene regulation, provided in part by microRNAs and RNA binding proteins, is becoming recognized as an important form of cellular control, especially as the significance of these regulators is better appreciated. Several RNA binding proteins are over-expressed in a variety of malignancies, including breast cancer. They have been shown to play a role in increased invasiveness of malignancy and poor prognosis for many cancers, as well as being implicated in tamoxifen resistance in breast cancer. Moreover, they have been described to control the expression of genes involved in transformation, and may serve as tumor maintenance genes.The current invention enables the identification, en masse, of in vivo targets of RNA binding proteins from cancer cells. This RIP-Chip technique allows one to identify en masse in vivo mRNA targets which interact with different RNA binding proteins.POTENTIAL AREAS OF APPLICATIONS:• Cancer diagnostic tests• Cancer therapeuticsMAIN ADVANTAGES OF INVENTION:• May lead to the identification of genes responsible for different subtypes of breast cancer• May identify novel breast cancer targets• Potentially identify genes which mediate tamoxifen resistance• Lead to the development of novel therapeutics that could overcome tamoxifen resistanceSTATE OF DEVELOPMENT:• Invention has undergone successful hybridization to microarrayLICENSING POTENTIAL:• University seeks licensee with the potential to commercializePATENT STATUS:• Provisional patent application has been filedINVENTORS:• Ulus Atasoy, Robert Calaluce, J. Wade DavisCONTACT INFO: Office of Technology Management & Industry Relations Harriet Francis, Sr. Licensing & Business Development Associate- Life Sciences Email: francish@missouri.edu Phone: 573-884-0374

*Principal Investigator

Name: Ulus Atasoy, Prof, Ast

Department:

Name: Robert Calaluce, Resrch Spclst Sr

Department:

Name: Justin Davis, Prof, Ast

Department:

Country/Region

USA