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X-Ray-Triggered Release of Drugs from Nanoscale Drug Carriers

Technology Benefits

Nanoparticles can be modified to suit drug Drug delivery can target specific cellular locations Ability to activate release of drug in target cell X-ray triggering method is already common component of clinical procedures Lower systemic toxicity Applicable to wide variety of drugs

Technology Application

Targeted delivery of small molecule therapeutics

Detailed Technology Description

Small molecule chemotherapeutics have been employed in cancer therapy.  However, their effectiveness is often hampered by systemic toxicity.  Although prodrugs have decreased systemic toxicity, they have met with limited success.  External triggering by microwaves, ultrasound, light, and magnetic fields, as well as natural triggering have been explored as a mechanism of drug molecule release, but all fall short due to lack of targeting precision or shallow penetration depths.  Thus, there exists a need for a drug delivery approach that can deliver a prodrug to a target cellular location and controllably release the drug at that target cellular location. Researchers at the University of California, Davis have identified a means by which large quantities of inactive drugs (particularly chemotherapeutics) can be delivered by nanoscale drug carriers to a target location where they can be rendered active by X-rays. Because X-rays are highly penetrating and have been used clinically in diagnosis and treatment of tumors, x-rays can potentially become a successful external triggering tool by cleaving the chemical bonds of the molecules linking the drug molecules to the nanoscale drug carriers for cell-specific delivery. The technology also allows for several variations of the nanosystem that make it amenable to a wide array of delivery targets and drugs.

Application No.

9993553

Others

Additional Technologies by these Inventors

• Enhancement of X-Ray Radiation Using Nanomaterials
• Formation of Polymers on Nanostructures Under X-ray Irradiation
• Measurement of Nanoscale Physical Enhancement by Materials under X-ray Irradiation
• Combined Individual Nanomaterial Enhancements for Total X-Ray Enhancement

Tech ID/UC Case

25582/2013-449-0

Related Cases

2013-449-0

*Abstract

Researchers at the University of California, Davis have identified a means by which large quantities of inactive drugs (particularly chemotherapeutics) can be delivered by nanoscale drug carriers to a target location where they can be rendered active by X-rays.

*IP Issue Date

Jun 12, 2018

*Principal Investigator

Name: Ting Guo

Department:

Name: Zane Starkewolfe

Department:

Country/Region

USA