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Fermented Wheat Germ Extract And Its Purified Low Molecular Weights Proteins For Treatment Of Lung Cancer

Technology Benefits

Purified active ingredient(s) Compounded ingredients in pill form Oral delivery

Technology Application

Treat patients with various forms of cancers, including lung cancer

Detailed Technology Description

Lung cancer is one of the most common cancers and is the leading cause of cancer death in the United States. Fermented wheat germ extract (FWGE) has purported health benefits and anti-cancer properties. However, the anti-cancer activities of FWGE in preclinical models and in humans have not been rigorously studied and the active ingredient(s) have yet to be identified. There is an unmet need for treatment of cancers refractory to traditional chemotherapy. In addition, there is no data assessing its efficacy against lung cancer in vitro or in vivo. Researchers at the University of California, Davis have isolated a mixture of low molecular weight fraction of proteins (LAP), consisting of 19 identifiable proteins. Furthermore, UC Davis researchers have demonstrated that fractionated FWGE is cytotoxic to human lung cancer in vitro by induction of apoptosis. FWGE also retards the growth of lung cancer xenograft in nude mice. The LAP, on a weight basis, is much more potent than FWGE itself in inhibiting growth of lung cancer cells.

Supplementary Information

Patent Number: US20120121612A1
Application Number: US13320898A
Inventor: Tuscano, Joseph | Lau, Derick | O'Donnell, Robert | Ma, Yunpeng
Priority Date: 20 May 2009
Priority Number: US20120121612A1
Application Date: 20 Jan 2012
Publication Date: 17 May 2012
IPC Current: A61K003802 | A61K003844 | A61K003848 | A61K003852 | A61K0039395 | A61P003500 | C12N000509
US Class: 4241741 | 4240944 | 4240945 | 42409463 | 435375 | 5140193 | 5140194
Assignee Applicant: United States Government as the Represented by theshington | Regents of the University of California,Oakland
Title: FERMENTED WHEAT GERM PROTEINS (FWGP) FOR THE TREATMENT OF CANCER
Usefulness: FERMENTED WHEAT GERM PROTEINS (FWGP) FOR THE TREATMENT OF CANCER
Summary: The composition is useful for preventing, reducing and/or inhibiting growth of cancer cell in vitro, or in vivo (in subject, preferably human). The cancer is chosen from lymphoma, lung cancer, breast cancer, colon cancer, and hepatic cancer, preferably lymphoma or lung cancer (all claimed). Can also be useful for preventing, reducing and/or inhibiting growth of cancer cell chosen from ovarian cancer, gastric and intestinal cancer, bladder cancer, renal cancer, head and neck cancer, esophageal cancer, hematological cancer and sarcoma.
Novelty: Composition useful for preventing, reducing and/or inhibiting growth of cancer e.g. lung cancer cell in subject, preferably human, comprises isolated fraction from fermented wheat germ extract and carrier

Industry

Disease Diagnostic/Treatment

Sub Category

Cancer/Tumor

Application No.

9480725

Others

Additional Technologies by these Inventors

• Antibody Targeted Therapy for Lung and Prostate Tumors
• Antisense Oligonucleotide Therapy for B Cell Mediated Cancers

Tech ID/UC Case

23913/2009-696-0

Related Cases

2009-696-0

*Abstract

Researchers at the University of California, Davis have demonstrated biologic activities of Fermented wheat germ extract (FWGE) against lung cancer cells in tissue culture and in mice.

*IP Issue Date

Nov 1, 2016

*Principal Investigator

Name: Derick HM Lau

Department:

Name: Robert O'Donnell

Department:

Name: Joseph Tuscano

Department:

Name: Derick HM Lau

Department:

Name: Robert O'Donnell

Department:

Name: Joseph Tuscano

Department:

Country/Region

USA